The Involvement of Semaphorins in the Pathogenesis of Skin Diseases
Abstract
:1. Introduction
2. Involvement of Semaphorins in Skin Diseases
3. Involvement of Semaphorins in the Etiopathogenesis of Psoriasis
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Type of Semaphorin | Skin Disease | Alterations Compared to Healthy Subjects | Major Effects on the Skin | References |
---|---|---|---|---|
Sema3A | Atopic dermatitis | decreased level of Sema3A expression in the epidermis | increased epidermal nerve fiber density | [19,29,30,31,48] |
Sema3A | Acute dry skin | decreased level of Sema3A expression in the epidermis | increased epidermal nerve fiber density | [20,21,22,23,31,48] |
Sema3A | Psoriasis | decreased level of Sema3A expression in the epidermis |
| [43,44,45,46,47,48,49] |
Sema4D | Oral lichen planus | upregulations of Sema4D in tissues and blood | induction of chemokines production, leading to CD8 T cells migration and recruitment | [34] |
Sema4D | Psoriasis | increased expression of Sema4D in tissues and blood | induction of inflammatory cytokines production in keratinocytes | [50] |
Sema7A | Psoriasis | expression of Sema7A regulated by various cytokines | promotion of the inflammation (monocyte activation and IL-8 production) | [51] |
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Słuczanowska-Głąbowska, S.; Jankowska, O.; Staniszewska, M.; Pawlik, A. The Involvement of Semaphorins in the Pathogenesis of Skin Diseases. Int. J. Mol. Sci. 2023, 24, 17235. https://doi.org/10.3390/ijms242417235
Słuczanowska-Głąbowska S, Jankowska O, Staniszewska M, Pawlik A. The Involvement of Semaphorins in the Pathogenesis of Skin Diseases. International Journal of Molecular Sciences. 2023; 24(24):17235. https://doi.org/10.3390/ijms242417235
Chicago/Turabian StyleSłuczanowska-Głąbowska, Sylwia, Olga Jankowska, Marzena Staniszewska, and Andrzej Pawlik. 2023. "The Involvement of Semaphorins in the Pathogenesis of Skin Diseases" International Journal of Molecular Sciences 24, no. 24: 17235. https://doi.org/10.3390/ijms242417235