Sulfated Polysaccharides as a Fighter with Protein Non-Physiological Aggregation: The Role of Polysaccharide Flexibility and Charge Density
Abstract
:1. Introduction
2. Results and Discussion
2.1. Band Assignments
2.2. HEWL Fibrils–Flexible κ-Carrageenan Mixtures
2.3. HEWL Fibril Mixtures with Flexible ι- or λ-Carrageenans
2.4. HEWL Fibril–Rigid κ-Carrageenan Mixtures
2.5. HEWL Fibril–Chondroitin-4-Sulfate Mixtures
3. Materials and Methods
3.1. Materials and Fibril Preparation
3.2. HEWL Fibril–Polysaccharide Mixing
3.3. FTIR Spectroscopy
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Makshakova, O.N.; Bogdanova, L.R.; Faizullin, D.A.; Ermakova, E.A.; Zuev, Y.F. Sulfated Polysaccharides as a Fighter with Protein Non-Physiological Aggregation: The Role of Polysaccharide Flexibility and Charge Density. Int. J. Mol. Sci. 2023, 24, 16223. https://doi.org/10.3390/ijms242216223
Makshakova ON, Bogdanova LR, Faizullin DA, Ermakova EA, Zuev YF. Sulfated Polysaccharides as a Fighter with Protein Non-Physiological Aggregation: The Role of Polysaccharide Flexibility and Charge Density. International Journal of Molecular Sciences. 2023; 24(22):16223. https://doi.org/10.3390/ijms242216223
Chicago/Turabian StyleMakshakova, Olga N., Liliya R. Bogdanova, Dzhigangir A. Faizullin, Elena A. Ermakova, and Yuriy F. Zuev. 2023. "Sulfated Polysaccharides as a Fighter with Protein Non-Physiological Aggregation: The Role of Polysaccharide Flexibility and Charge Density" International Journal of Molecular Sciences 24, no. 22: 16223. https://doi.org/10.3390/ijms242216223