Cellular Senescence, Inflammation, and Cancer in the Gastrointestinal Tract
Abstract
:1. Introduction
2. Cellular Senescence
3. Senescence in GI Mucosa and Muscle
4. Immunosenescence
5. Inflammatory Bowel Disease
6. Esophagitis
7. Helicobacter pylori, Senescence, and Gastric Cancer
8. Cellular Senescence in GI Cancers and GIST
9. Senotherapeutics and Clinical Trials
10. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
ABCs | Age-associated B cells |
CRC | Colorectal cancer |
GALT | Gut-associated lymphoid tissue |
GI | Gastrointestinal tract |
GIST | Gastrointestinal stromal tumor |
H2S | Hydrogen sulfide |
IBD | Inflammatory bowel disease |
ICCs | Interstitial cells of Cajal |
IL | Interleukin |
SASP | Senescence-associated secretory phenotype |
UC | Ulcerative colitis |
Gene/Protein Expansions | |
CXCR | C-X-C motif chemokine receptor |
DREAM | Dimerization partner, RB-like, E2F and multi-vulval class B |
DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A |
ERK | Extracellular signal-regulated kinase |
GDF15 | Growth differentiation factor 15 |
KIT | KIT proto-oncogene, receptor tyrosine kinase |
miR-20a-5p | MicroRNA-20a-5p |
MYC | MYC proto-oncogene, bHLH transcription factor |
PTEN | Phosphatase and tension homolog |
PUMA | p53 upregulated modulator of apoptosis |
SENP1 | SUMO specific peptidase 1 |
TGFβ | Transforming growth factor β |
TLR | Toll-like receptor |
Wnt | Wingless/integrated |
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Choi, E.L.; Taheri, N.; Chandra, A.; Hayashi, Y. Cellular Senescence, Inflammation, and Cancer in the Gastrointestinal Tract. Int. J. Mol. Sci. 2023, 24, 9810. https://doi.org/10.3390/ijms24129810
Choi EL, Taheri N, Chandra A, Hayashi Y. Cellular Senescence, Inflammation, and Cancer in the Gastrointestinal Tract. International Journal of Molecular Sciences. 2023; 24(12):9810. https://doi.org/10.3390/ijms24129810
Chicago/Turabian StyleChoi, Egan L., Negar Taheri, Abhishek Chandra, and Yujiro Hayashi. 2023. "Cellular Senescence, Inflammation, and Cancer in the Gastrointestinal Tract" International Journal of Molecular Sciences 24, no. 12: 9810. https://doi.org/10.3390/ijms24129810