Roles of Fibroblast Growth Factors in the Axon Guidance
Abstract
:1. Introduction
2. Background of FGFs in the Development of Nervous System
3. Effects of FGFs on the Axon Guidance
3.1. Direct Axon Guidance Effects of FGFs in Vertebrates
3.2. Indirect Axon Guidance Effects of FGFs in Vertebrates
3.3. FGF’s Axon Guidance Functions in Invertebrates
4. Concentration-Dependent Responses of Growth Cones to FGFs
4.1. Continuous Changed Responses of the Same Axons over Time and Space
4.2. The Molecular Mechanism behind the Concentration-Dependent Responses
5. FGFs and FGFRs Interaction
5.1. Why FGFs Exert Distinct Effects on Different Axons
5.2. The Importance of the FGF-FGFR System in Axon Pathfinding
6. Common Downstream Signaling Mechanisms
6.1. Three Major FGF Signaling Pathways
6.2. Common Cytoskeletal Alterations
6.3. Recruitment and Convergence of FGF Signaling Pathways
7. Summary and Perspective
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Axons | FGFs | Effects | Note | References |
---|---|---|---|---|
Medial motor column (MMCm) axons | FGF2, 4, 8, 9 | Attractive | Directly | [39,40] |
Statoacoustic ganglion (SAG) neurites | FGF8, 10, 19 | Promote asymmetric outgrowth | Directly | [41] |
Thalamocortical axons (TCA) | FGF3, 10 | Low concentration: attractive | Directly | [42,43] |
High concentration: repulsive | ||||
Hypothalamic axons | FGF3, 10 | Low concentration: attractive | Directly | [44] |
High concentration: repulsive | ||||
Midbrain dopaminergic neuron (mDAN) axons | FGF8 | Repulsive | Indirectly | [45] |
Trochlear motor axons | FGF8 | Attractive | Directly | [31] |
Retinal ganglion cell (RGC) axons | FGF2 | Repulsive | Directly | [46,47] |
RGC axons | FGF8 | Repulsive | Indirectly | [33] |
FGFRs | Main Sites | Expression Phases |
---|---|---|
FGFR1 | Neurons [100,101] | In embryonic and adult development [97,102] |
FGFR2 | Oligodendrocytes [100,101] | In embryonic and adult development [97,102] |
FGFR3 | Astrocytes [101] | In embryonic and adult development [97,102] |
FGFR4 | Neurons [101] | Only in embryonic development but not in the adult brain apart from the lateral habenular nucleus [103] |
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Zhang, W.; Luo, P.; Liu, X.; Cheng, R.; Zhang, S.; Qian, X.; Liu, F. Roles of Fibroblast Growth Factors in the Axon Guidance. Int. J. Mol. Sci. 2023, 24, 10292. https://doi.org/10.3390/ijms241210292
Zhang W, Luo P, Liu X, Cheng R, Zhang S, Qian X, Liu F. Roles of Fibroblast Growth Factors in the Axon Guidance. International Journal of Molecular Sciences. 2023; 24(12):10292. https://doi.org/10.3390/ijms241210292
Chicago/Turabian StyleZhang, Weiyun, Peiyi Luo, Xiaohan Liu, Ruoxi Cheng, Shuxian Zhang, Xiao Qian, and Fang Liu. 2023. "Roles of Fibroblast Growth Factors in the Axon Guidance" International Journal of Molecular Sciences 24, no. 12: 10292. https://doi.org/10.3390/ijms241210292