Consideration for Flavonoid-Containing Dietary Supplements to Tackle Deficiency and Optimize Health
Abstract
:1. Introduction
2. Micronutrient Deficiencies Are Common
3. Healthy Foods Contain Many Micronutrients, Not Just Vitamins and Minerals
4. Flavonoids
4.1. Human Research
Clinical Benefits | Reference |
---|---|
Decreased risk of coronary artery disease & cardiovascular disease mortality | Bondonno et al., 2019 [45], Micek et al., 2021 [41], Fusi et al., 2020 [42], Singh et al., 2002 [48] |
Decreased risk of cognitive decline, Lower risks of Alzheimer disease & related dementias, Lower risks of Parkinson’s disease | Yeh et al., 2021 [40], Shishtar et al., 2020 [44], Talebi et al., 2022 [43] |
Improvements in metabolic health (e.g., blood lipids, blood glucose and blood pressure) & insulin resistance | Gouveia et al., 2022 [50], Testa et al., 2016 [52], Al-Ishaq et al., 2019 [53], Martín and Ramos 2021 [51] |
Inhibition of chronic inflammatory conditions, Reduction in pro-inflammatory cytokines e.g., IL-6 | Ginwala et al., 2019 [58], DeRango-Adem and Blay 2021 [59], Al-Aubaidy et al., 2021 [49] |
Reduced risk of hormone-related cancers (e.g., breast, ovarian cancer) | Liu et al., 2022 [62], Hui et al., 2013 [63] |
Inhibition of platelet aggregation and thrombus formation | Tamer et al., 2022 [64], Hubbard et al., 2004 [65] |
Prevention of COVID-19, Reduction in frequency & length of hospitalization, faster recovery time of COVID-19 | Rondanelli et al., 2022 [70], Di Pierro et al., 2021a [71], Di Pierro et al., 2021b [72] |
4.2. Flavonoid Bioavailability
4.3. Ways to Improve Flavonoid Absorption and Clinical Benefit
4.4. Interactions
5. Conclusions and Future Directions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Solnier, J.; Chang, C.; Pizzorno, J. Consideration for Flavonoid-Containing Dietary Supplements to Tackle Deficiency and Optimize Health. Int. J. Mol. Sci. 2023, 24, 8663. https://doi.org/10.3390/ijms24108663
Solnier J, Chang C, Pizzorno J. Consideration for Flavonoid-Containing Dietary Supplements to Tackle Deficiency and Optimize Health. International Journal of Molecular Sciences. 2023; 24(10):8663. https://doi.org/10.3390/ijms24108663
Chicago/Turabian StyleSolnier, Julia, Chuck Chang, and Joseph Pizzorno. 2023. "Consideration for Flavonoid-Containing Dietary Supplements to Tackle Deficiency and Optimize Health" International Journal of Molecular Sciences 24, no. 10: 8663. https://doi.org/10.3390/ijms24108663