Stress-Induced Membraneless Organelles in Eukaryotes and Prokaryotes: Bird’s-Eye View
Abstract
:1. Introduction
2. Stress-Induced Membraneless Organelles in Eukaryotes
2.1. Stress Granules
2.2. A-Bodies
2.3. Nuclear Stress-Bodies
3. Stress-Induced Membraneless Organelles in Prokaryotes
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Organelle | Key Players | Organism | Function |
---|---|---|---|
BR-body | mRNA, RNase E, Enolace, RhIB ATPase, PNPase, sRNA | Escherichia coli [78] Caulobacter crescentus [79] Sinorhizobium meliloti, Agrobacterium tumefacienes, Cyanobacteria [19] | mRNA decay. Formation is stimulated by cellular stress and following inhibition of translation |
RNAP cluster | RNAP, NusA, rRNA operons | Escherichia coli [19] | rRNA transcription |
IbpA granular bodies | IbpA | Acholeplasma laidlawii [83] | Stress-induced bodies involved in heat-shock response |
ParABS protein system | ParA, ParB, ParS | Corynebacterium glutamicum [84] | plasmids and chromosome segregation |
Bacterial DEAD box ATPases | Bacterial DEAD box ATPases, RhlB | Escherichia coli [85] | DEAD box ATPases have been shown to promote phase separation in their ATP-bound form. RhIB is a component of BR-bodies and involved in mRNA decay processes |
SSB condensates | SSB | Escherichia coli [82] | Protection of single-stranded DNA during replication, recombination and repair |
PopZ microdomains | PopZ | Caulobacter crescentus [80,81] | Polar organization during asymmetrical cell division |
SpmX condensates | SpmX | Caulobacter crescentus [81] | Polar organization during asymmetrical cell division |
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Fefilova, A.S.; Fonin, A.V.; Vishnyakov, I.E.; Kuznetsova, I.M.; Turoverov, K.K. Stress-Induced Membraneless Organelles in Eukaryotes and Prokaryotes: Bird’s-Eye View. Int. J. Mol. Sci. 2022, 23, 5010. https://doi.org/10.3390/ijms23095010
Fefilova AS, Fonin AV, Vishnyakov IE, Kuznetsova IM, Turoverov KK. Stress-Induced Membraneless Organelles in Eukaryotes and Prokaryotes: Bird’s-Eye View. International Journal of Molecular Sciences. 2022; 23(9):5010. https://doi.org/10.3390/ijms23095010
Chicago/Turabian StyleFefilova, Anna S., Alexander V. Fonin, Innokentii E. Vishnyakov, Irina M. Kuznetsova, and Konstantin K. Turoverov. 2022. "Stress-Induced Membraneless Organelles in Eukaryotes and Prokaryotes: Bird’s-Eye View" International Journal of Molecular Sciences 23, no. 9: 5010. https://doi.org/10.3390/ijms23095010