Next Article in Journal
Molecular Methodologies for Improved Polymicrobial Sepsis Diagnosis
Next Article in Special Issue
The Final Frontier of Sustainable Materials: Current Developments in Self-Healing Elastomers
Previous Article in Journal
Examination of the Impact of CYP3A4/5 on Drug–Drug Interaction between Schizandrol A/Schizandrol B and Tacrolimus (FK-506): A Physiologically Based Pharmacokinetic Modeling Approach

Alginate: Enhancement Strategies for Advanced Applications

Biomaterials and Bioengineering Laboratory, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, c/Guillem de Castro 94, 46001 Valencia, Spain
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University, Irbid 21163, Jordan
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, India
School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine BT52 1SA, Northern Ireland, UK
Author to whom correspondence should be addressed.
Academic Editor: Xiao Hu
Int. J. Mol. Sci. 2022, 23(9), 4486;
Received: 12 March 2022 / Revised: 14 April 2022 / Accepted: 17 April 2022 / Published: 19 April 2022
(This article belongs to the Collection State-of-the-Art Macromolecules in Spain)
Alginate is an excellent biodegradable and renewable material that is already used for a broad range of industrial applications, including advanced fields, such as biomedicine and bioengineering, due to its excellent biodegradable and biocompatible properties. This biopolymer can be produced from brown algae or a microorganism culture. This review presents the principles, chemical structures, gelation properties, chemical interactions, production, sterilization, purification, types, and alginate-based hydrogels developed so far. We present all of the advanced strategies used to remarkably enhance this biopolymer’s physicochemical and biological characteristics in various forms, such as injectable gels, fibers, films, hydrogels, and scaffolds. Thus, we present here all of the material engineering enhancement approaches achieved so far in this biopolymer in terms of mechanical reinforcement, thermal and electrical performance, wettability, water sorption and diffusion, antimicrobial activity, in vivo and in vitro biological behavior, including toxicity, cell adhesion, proliferation, and differentiation, immunological response, biodegradation, porosity, and its use as scaffolds for tissue engineering applications. These improvements to overcome the drawbacks of the alginate biopolymer could exponentially increase the significant number of alginate applications that go from the paper industry to the bioprinting of organs. View Full-Text
Keywords: alginate; biopolymer; hydrogel; enhanced properties; composites alginate; biopolymer; hydrogel; enhanced properties; composites
Show Figures

Figure 1

MDPI and ACS Style

Hurtado, A.; Aljabali, A.A.A.; Mishra, V.; Tambuwala, M.M.; Serrano-Aroca, Á. Alginate: Enhancement Strategies for Advanced Applications. Int. J. Mol. Sci. 2022, 23, 4486.

AMA Style

Hurtado A, Aljabali AAA, Mishra V, Tambuwala MM, Serrano-Aroca Á. Alginate: Enhancement Strategies for Advanced Applications. International Journal of Molecular Sciences. 2022; 23(9):4486.

Chicago/Turabian Style

Hurtado, Alejandro, Alaa A. A. Aljabali, Vijay Mishra, Murtaza M. Tambuwala, and Ángel Serrano-Aroca. 2022. "Alginate: Enhancement Strategies for Advanced Applications" International Journal of Molecular Sciences 23, no. 9: 4486.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop