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Volume 23
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10.3390/ijms23084205
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Review

The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System

by
Jan Korbecki
1,2,
Magdalena Gąssowska-Dobrowolska
3,
Jerzy Wójcik
2,
Iwona Szatkowska
2,
Katarzyna Barczak
4,
Mikołaj Chlubek
1 and
Irena Baranowska-Bosiacka
1,*
1
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp. 72 Av., 70-111 Szczecin, Poland
2
Department of Ruminants Science, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology, Klemensa Janickiego 29 St., 71-270 Szczecin, Poland
3
Department of Cellular Signalling, Mossakowski Medical Research Institute, Polish Academy of Sciences, Pawińskiego 5, 02-106 Warsaw, Poland
4
Department of Conservative Dentistry and Endodontics, Pomeranian Medical University, Powstańców Wlkp. 72 Av., 70-111 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(8), 4205; https://doi.org/10.3390/ijms23084205
Submission received: 24 March 2022 / Revised: 8 April 2022 / Accepted: 9 April 2022 / Published: 11 April 2022
(This article belongs to the Special Issue Immune Mediators and Disruptors of Neural Functions)
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Abstract

This review describes the role of CXCL1, a chemokine crucial in inflammation as a chemoattractant for neutrophils, in physiology and in selected major non-cancer diseases. Due to the vast amount of available information, we focus on the role CXCL1 plays in the physiology of bones, bone marrow, muscle and the nervous system. For this reason, we describe its effects on hematopoietic stem cells, myoblasts, oligodendrocyte progenitors and osteoclast precursors. We also present the involvement of CXCL1 in diseases of selected tissues and organs including Alzheimer’s disease, epilepsy, herpes simplex virus type 1 (HSV-1) encephalitis, ischemic stroke, major depression, multiple sclerosis, neuromyelitis optica, neuropathic pain, osteoporosis, prion diseases, rheumatoid arthritis, tick-borne encephalitis (TBE), traumatic spinal cord injury and West Nile fever.
Keywords: CXCL1; CXCR2; brain; chemokine; cytokine; neutrophil; CINC-1; KC; Gro-α CXCL1; CXCR2; brain; chemokine; cytokine; neutrophil; CINC-1; KC; Gro-α
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MDPI and ACS Style

Korbecki, J.; Gąssowska-Dobrowolska, M.; Wójcik, J.; Szatkowska, I.; Barczak, K.; Chlubek, M.; Baranowska-Bosiacka, I. The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System. Int. J. Mol. Sci. 2022, 23, 4205. https://doi.org/10.3390/ijms23084205

AMA Style

Korbecki J, Gąssowska-Dobrowolska M, Wójcik J, Szatkowska I, Barczak K, Chlubek M, Baranowska-Bosiacka I. The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System. International Journal of Molecular Sciences. 2022; 23(8):4205. https://doi.org/10.3390/ijms23084205

Chicago/Turabian Style

Korbecki, Jan, Magdalena Gąssowska-Dobrowolska, Jerzy Wójcik, Iwona Szatkowska, Katarzyna Barczak, Mikołaj Chlubek, and Irena Baranowska-Bosiacka. 2022. "The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System" International Journal of Molecular Sciences 23, no. 8: 4205. https://doi.org/10.3390/ijms23084205

APA Style

Korbecki, J., Gąssowska-Dobrowolska, M., Wójcik, J., Szatkowska, I., Barczak, K., Chlubek, M., & Baranowska-Bosiacka, I. (2022). The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System. International Journal of Molecular Sciences, 23(8), 4205. https://doi.org/10.3390/ijms23084205

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