Next Article in Journal
Necroptosis as a Novel Facet of Mitotic Catastrophe
Next Article in Special Issue
Impact of Epithelial Cell Shedding on Intestinal Homeostasis
Previous Article in Journal
The Roles of BLH Transcription Factors in Plant Development and Environmental Response
Previous Article in Special Issue
The Epithelial Cell Leak Pathway
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 23
Issue 7
10.3390/ijms23073732
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Enteroendocrine System and Gut Barrier in Metabolic Disorders

by
Céline Osinski
1,
Dounia Moret
1,
Karine Clément
1,2,
Patricia Serradas
1,*,† and
Agnès Ribeiro
1,*,†
1
NutriOmics, Research Group, INSERM, Nutrition and Obesities: Systemic Approaches, Sorbonne Université, F-75013 Paris, France
2
Nutrition Department, Pitié-Salpêtrière Hospital, Assistance Publique/Hôpitaux de Paris, F-75013 Paris, France
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2022, 23(7), 3732; https://doi.org/10.3390/ijms23073732
Submission received: 2 March 2022 / Revised: 25 March 2022 / Accepted: 26 March 2022 / Published: 29 March 2022
(This article belongs to the Special Issue Regulation and Physiopathology of Gut Barrier)
Browse Figures
Review Reports Versions Notes

Abstract

With the continuous rise in the worldwide prevalence of obesity and type 2 diabetes, developing therapies regulating body weight and glycemia has become a matter of great concern. Among the current treatments, evidence now shows that the use of intestinal hormone analogs (e.g., GLP1 analogs and others) helps to control glycemia and reduces body weight. Indeed, intestinal endocrine cells produce a large variety of hormones regulating metabolism, including appetite, digestion, and glucose homeostasis. Herein, we discuss how the enteroendocrine system is affected by local environmental and metabolic signals. These signals include those arising from unbalanced diet, gut microbiota, and the host metabolic organs and their complex cross-talk with the intestinal barrier integrity.
Keywords: enteroendocrine cells; cell lineage; intestinal hormones; obesity; type 2 diabetes; diets; microbiota; gut barrier integrity enteroendocrine cells; cell lineage; intestinal hormones; obesity; type 2 diabetes; diets; microbiota; gut barrier integrity

Share and Cite

MDPI and ACS Style

Osinski, C.; Moret, D.; Clément, K.; Serradas, P.; Ribeiro, A. Enteroendocrine System and Gut Barrier in Metabolic Disorders. Int. J. Mol. Sci. 2022, 23, 3732. https://doi.org/10.3390/ijms23073732

AMA Style

Osinski C, Moret D, Clément K, Serradas P, Ribeiro A. Enteroendocrine System and Gut Barrier in Metabolic Disorders. International Journal of Molecular Sciences. 2022; 23(7):3732. https://doi.org/10.3390/ijms23073732

Chicago/Turabian Style

Osinski, Céline, Dounia Moret, Karine Clément, Patricia Serradas, and Agnès Ribeiro. 2022. "Enteroendocrine System and Gut Barrier in Metabolic Disorders" International Journal of Molecular Sciences 23, no. 7: 3732. https://doi.org/10.3390/ijms23073732

APA Style

Osinski, C., Moret, D., Clément, K., Serradas, P., & Ribeiro, A. (2022). Enteroendocrine System and Gut Barrier in Metabolic Disorders. International Journal of Molecular Sciences, 23(7), 3732. https://doi.org/10.3390/ijms23073732

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop