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Review

Insights into Infusion-Based Targeted Drug Delivery in the Brain: Perspectives, Challenges and Opportunities

1
Department of Mechanical Engineering, Imperial College London, London SW7 2AZ, UK
2
Vita-Salute San Raffaele University, 20132 Milan, Italy
3
Neuroradiology Unit and CERMAC, IRCCS Ospedale San Raffaele, 20132 Milan, Italy
4
Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Via Festa del Perdono 7, 20122 Milan, Italy
5
Department of Oncology and Hematology-Oncology, Universitá degli Studi di Milano, 20122 Milan, Italy
*
Authors to whom correspondence should be addressed.
Academic Editors: Ida Genta and Bice Conti
Int. J. Mol. Sci. 2022, 23(6), 3139; https://doi.org/10.3390/ijms23063139
Received: 25 February 2022 / Revised: 9 March 2022 / Accepted: 10 March 2022 / Published: 15 March 2022
(This article belongs to the Special Issue Challenges, Opportunities, and Innovation in Local Drug Delivery)
Targeted drug delivery in the brain is instrumental in the treatment of lethal brain diseases, such as glioblastoma multiforme, the most aggressive primary central nervous system tumour in adults. Infusion-based drug delivery techniques, which directly administer to the tissue for local treatment, as in convection-enhanced delivery (CED), provide an important opportunity; however, poor understanding of the pressure-driven drug transport mechanisms in the brain has hindered its ultimate success in clinical applications. In this review, we focus on the biomechanical and biochemical aspects of infusion-based targeted drug delivery in the brain and look into the underlying molecular level mechanisms. We discuss recent advances and challenges in the complementary field of medical robotics and its use in targeted drug delivery in the brain. A critical overview of current research in these areas and their clinical implications is provided. This review delivers new ideas and perspectives for further studies of targeted drug delivery in the brain. View Full-Text
Keywords: convection-enhanced delivery; brain; infusion; fluid flow; mass transport; tissue deformation; molecular interactions convection-enhanced delivery; brain; infusion; fluid flow; mass transport; tissue deformation; molecular interactions
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MDPI and ACS Style

Jamal, A.; Yuan, T.; Galvan, S.; Castellano, A.; Riva, M.; Secoli, R.; Falini, A.; Bello, L.; Rodriguez y Baena, F.; Dini, D. Insights into Infusion-Based Targeted Drug Delivery in the Brain: Perspectives, Challenges and Opportunities. Int. J. Mol. Sci. 2022, 23, 3139. https://doi.org/10.3390/ijms23063139

AMA Style

Jamal A, Yuan T, Galvan S, Castellano A, Riva M, Secoli R, Falini A, Bello L, Rodriguez y Baena F, Dini D. Insights into Infusion-Based Targeted Drug Delivery in the Brain: Perspectives, Challenges and Opportunities. International Journal of Molecular Sciences. 2022; 23(6):3139. https://doi.org/10.3390/ijms23063139

Chicago/Turabian Style

Jamal, Asad, Tian Yuan, Stefano Galvan, Antonella Castellano, Marco Riva, Riccardo Secoli, Andrea Falini, Lorenzo Bello, Ferdinando Rodriguez y Baena, and Daniele Dini. 2022. "Insights into Infusion-Based Targeted Drug Delivery in the Brain: Perspectives, Challenges and Opportunities" International Journal of Molecular Sciences 23, no. 6: 3139. https://doi.org/10.3390/ijms23063139

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