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Review

Piezoelectric Electrospun Fibrous Scaffolds for Bone, Articular Cartilage and Osteochondral Tissue Engineering

1
iBB—Institute for Bioengineering and Biosciences, Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
2
Associate Laboratory i4HB—Institute for Health and Bioeconomy, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
3
CDRSP—Centre for Rapid and Sustainable Product Development, Polytechnic of Leiria, Rua de Portugal-Zona Industrial, 2430-028 Marinha Grande, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Ihtesham Ur Rehman
Int. J. Mol. Sci. 2022, 23(6), 2907; https://doi.org/10.3390/ijms23062907
Received: 17 January 2022 / Revised: 26 February 2022 / Accepted: 2 March 2022 / Published: 8 March 2022
(This article belongs to the Special Issue Biomaterials and Regenerative Medicine)
Osteochondral tissue (OCT) related diseases, particularly osteoarthritis, number among the most prevalent in the adult population worldwide. However, no satisfactory clinical treatments have been developed to date to resolve this unmet medical issue. Osteochondral tissue engineering (OCTE) strategies involving the fabrication of OCT-mimicking scaffold structures capable of replacing damaged tissue and promoting its regeneration are currently under development. While the piezoelectric properties of the OCT have been extensively reported in different studies, they keep being neglected in the design of novel OCT scaffolds, which focus primarily on the tissue’s structural and mechanical properties. Given the promising potential of piezoelectric electrospun scaffolds capable of both recapitulating the piezoelectric nature of the tissue’s fibrous ECM and of providing a platform for electrical and mechanical stimulation to promote the regeneration of damaged OCT, the present review aims to examine the current state of the art of these electroactive smart scaffolds in OCTE strategies. A summary of the piezoelectric properties of the different regions of the OCT and an overview of the main piezoelectric biomaterials applied in OCTE applications are presented. Some recent examples of piezoelectric electrospun scaffolds developed for potentially replacing damaged OCT as well as for the bone or articular cartilage segments of this interfacial tissue are summarized. Finally, the current challenges and future perspectives concerning the use of piezoelectric electrospun scaffolds in OCT regeneration are discussed. View Full-Text
Keywords: articular cartilage; bone; electrospinning; piezoelectric fibrous scaffolds; osteochondral tissue; tissue engineering articular cartilage; bone; electrospinning; piezoelectric fibrous scaffolds; osteochondral tissue; tissue engineering
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MDPI and ACS Style

Barbosa, F.; Ferreira, F.C.; Silva, J.C. Piezoelectric Electrospun Fibrous Scaffolds for Bone, Articular Cartilage and Osteochondral Tissue Engineering. Int. J. Mol. Sci. 2022, 23, 2907. https://doi.org/10.3390/ijms23062907

AMA Style

Barbosa F, Ferreira FC, Silva JC. Piezoelectric Electrospun Fibrous Scaffolds for Bone, Articular Cartilage and Osteochondral Tissue Engineering. International Journal of Molecular Sciences. 2022; 23(6):2907. https://doi.org/10.3390/ijms23062907

Chicago/Turabian Style

Barbosa, Frederico, Frederico C. Ferreira, and João C. Silva. 2022. "Piezoelectric Electrospun Fibrous Scaffolds for Bone, Articular Cartilage and Osteochondral Tissue Engineering" International Journal of Molecular Sciences 23, no. 6: 2907. https://doi.org/10.3390/ijms23062907

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