Comparison of Injectable Biphasic Calcium Phosphate and a Bovine Xenograft in Socket Preservation: Qualitative and Quantitative Histologic Study in Humans

Čandrlić, Marija; Tomas, Matej; Karl, Matej; Malešić, Lucija; Včev, Aleksandar; Perić Kačarević, Željka; Matijević, Marko

doi:10.3390/ijms23052539

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Comparison of Injectable Biphasic Calcium Phosphate and a Bovine Xenograft in Socket Preservation: Qualitative and Quantitative Histologic Study in Humans

^1,2,†

^1,†

^1,2,3,

⁴,

⁵,

Željka Perić Kačarević

^6,*

and

Marko Matijević

^7,*

Department of Dental Medicine, Faculty of Dental Medicine and Health Osijek, J. J. Strossmayer University of Osijek, 31000 Osijek, Croatia

Faculty of Medicine Osijek, J. J. Strossmayer University of Osijek, 31000 Osijek, Croatia

Private Dental Practice Matej Karl, Prilaz Vilka Ivekovića 1, 31511 Belišće, Croatia

⁴

Department of Anatomy, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia

⁵

Department of Pathophysiology, Physiology and Immunology, Faculty of Dental medicine and Health Osijek, J. J. Strossmayer University of Osijek, 31000 Osijek, Croatia

⁶

Department of Anatomy, Histology, Embriology, Pathology Anatomy and Pathology Histology, Faculty of Dental Medicine and Health Osijek, J. J. Strossmayer University of Osijek, 31000 Osijek, Croatia

⁷

Community Healthcare Center of Osijek-Baranja County, 31000 Osijek, Croatia

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Academic Editor: Ihtesham Ur Rehman

Int. J. Mol. Sci. 2022, 23(5), 2539; https://doi.org/10.3390/ijms23052539

Received: 8 February 2022 / Revised: 21 February 2022 / Accepted: 24 February 2022 / Published: 25 February 2022

(This article belongs to the Special Issue Biomaterials and Regenerative Medicine)

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Abstract

This study is the first histologic evaluation of an injectable biphasic calcium phosphate (IBCP) in humans six months after socket preservation according to the principles of guided bone regeneration. After tooth extraction, the alveolar ridge of 21 patients was augmented with IBCP (maxresorb^® inject) in the test group, while 20 patients in the control group received a bovine xenograft (BX) (cerabone^®). Six months after augmentation, a reentry procedure was performed to collect biopsies of regenerated bone for qualitative and quantitative histologic analysis. A total of 20 biopsies were taken for analysis. Qualitative histologic analysis showed complete integration of the biomaterial and no inflammatory tissue reaction, indicating the biocompatibility of the bone grafts and the surrounding tissue in both groups. Histomorphometric analysis showed comparable results in terms of newly formed bone (IBCP: 26.47 ± 14.71%, BX: 30.47 ± 16.39%) and residual biomaterial (IBCP: 13.1 ± 14.07%, BX: 17.89 ± 11.81%), with no significant difference found across groups (p > 0.05, Mann—Whitney U test). Statistical significance between groups was found in the result of soft tissue percentage (IBCP: 60.43 ± 12.73%, BX: 51.64 ± 14.63%, p = 0.046, Mann—Whitney U test). To conclude, IBCP and BX showed good osteoconductivity and biocompatibility with comparable new bone formation six months after alveolar ridge preservation. View Full-Text

Keywords: socket preservation; guided bone regeneration; biphasic calcium phosphate; xenograft; tissue engineering; qualitative histology; quantitative histology

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Čandrlić, M.; Tomas, M.; Karl, M.; Malešić, L.; Včev, A.; Perić Kačarević, Ž.; Matijević, M. Comparison of Injectable Biphasic Calcium Phosphate and a Bovine Xenograft in Socket Preservation: Qualitative and Quantitative Histologic Study in Humans. Int. J. Mol. Sci. 2022, 23, 2539. https://doi.org/10.3390/ijms23052539

AMA Style

Čandrlić M, Tomas M, Karl M, Malešić L, Včev A, Perić Kačarević Ž, Matijević M. Comparison of Injectable Biphasic Calcium Phosphate and a Bovine Xenograft in Socket Preservation: Qualitative and Quantitative Histologic Study in Humans. International Journal of Molecular Sciences. 2022; 23(5):2539. https://doi.org/10.3390/ijms23052539

Chicago/Turabian Style

Čandrlić, Marija, Matej Tomas, Matej Karl, Lucija Malešić, Aleksandar Včev, Željka Perić Kačarević, and Marko Matijević. 2022. "Comparison of Injectable Biphasic Calcium Phosphate and a Bovine Xenograft in Socket Preservation: Qualitative and Quantitative Histologic Study in Humans" International Journal of Molecular Sciences 23, no. 5: 2539. https://doi.org/10.3390/ijms23052539

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Comparison of Injectable Biphasic Calcium Phosphate and a Bovine Xenograft in Socket Preservation: Qualitative and Quantitative Histologic Study in Humans

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