Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors

Round 1

Reviewer 1 Report

This is a very interesting review paper on glyoxalase modulators and their clinical applications. The manuscript is comprehensive (128 references in total) and well written. Tables are very helpful. Graphical part is also attractive. I have no major comments/concerns.

Minor points:

The authors should add a paragraph on future perspective.

Limitations should be also more highlighted as a separate paragraph.

Author Response

We thank the Reviewer for the supportive comments.

MINOR POINT 1 “The authors should add a paragraph on future perspective”

AUTHORS’ RESPONSE: We have added two paragraphs – one on future perspective on each of Glo1 inducers and Glo1 inhibitors (Page 19, lines 3 – 17 and Page 20, lines 7 – 13).

MINOR POINT 2 “Limitations should be also more highlighted as a separate paragraph”.

AUTHORS’ RESPONSE: We have added two paragraphs – one on limitations on each of Glo1 inducers and Glo1 inhibitors (Page 19, lines 18 – 25 and Page 20, lines 14 – 20).

ADDITIONAL CHANGES: We have checked and made improvements in English language style and checked for typographical errors.

(Modifications made in the revised manuscript are indicated in blue font).

Reviewer 2 Report

In this manuscript, the authors reviewed about glyoxalase 1 inducers and glyoxalase 1 inhibitors.

This review article is well organized and provides an overview of the latest information in this field.

Author Response

We thank the reviewer for the supportive comments.

We have checked and made improvements in English language style and checked for typographical errors.

(Modifications made in the revised manuscript are indicated in blue font).