Alteration of Ethanol Reward by Prior Mephedrone Exposure: The Role of Age and Matrix Metalloproteinase-9 (MMP-9)
Abstract
:1. Introduction
2. Results
2.1. Ethanol CPP
2.2. Effect of Mephedrone Pretreatment on Ethanol CPP in Adult and Adolescent Rats
2.3. Influence of Minocycline Pretreatment on the Mephedrone Effect on the Ethanol CPP in Adult Rats
2.4. Biochemical Experiments
2.4.1. Effect of Mephedrone Pretreatment, Ethanol Treatment, and Age of Rats on D1R Expression in the vSTR
2.4.2. Effect of Mephedrone Pretreatment, Ethanol Treatment, and Age of Rats on Cav1.2 Expression in the vSTR
2.4.3. Effect of Mephedrone Pretreatment, Ethanol Treatment, and Age of Rats on MMP-9 Expression in the vSTR
2.4.4. Influence of Minocycline Pretreatment on the Mephedrone Effect on MMP-9 Expression in the vSTR
2.4.5. Effect of Mephedrone Treatment on the Expression of NMDAR Subunits (GluN1, GluN2A, and GluN2B) in the vSTR
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Drugs
4.3. CPP Apparatus
4.4. CPP Procedure
4.4.1. The Effect of Mephedrone Pretreatment on the Ethanol CPP
4.4.2. The Influence of Minocycline Pretreatment on the Mephedrone Effect on the Ethanol CPP
4.4.3. The Ethanol CPP
4.5. Biochemical Experiments
4.5.1. ELISA Assay
4.5.2. Western Blot
4.6. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Grochecki, P.; Smaga, I.; Marszalek-Grabska, M.; Lopatynska-Mazurek, M.; Slowik, T.; Gibula-Tarlowska, E.; Kedzierska, E.; Listos, J.; Filip, M.; Kotlinska, J.H. Alteration of Ethanol Reward by Prior Mephedrone Exposure: The Role of Age and Matrix Metalloproteinase-9 (MMP-9). Int. J. Mol. Sci. 2022, 23, 2122. https://doi.org/10.3390/ijms23042122
Grochecki P, Smaga I, Marszalek-Grabska M, Lopatynska-Mazurek M, Slowik T, Gibula-Tarlowska E, Kedzierska E, Listos J, Filip M, Kotlinska JH. Alteration of Ethanol Reward by Prior Mephedrone Exposure: The Role of Age and Matrix Metalloproteinase-9 (MMP-9). International Journal of Molecular Sciences. 2022; 23(4):2122. https://doi.org/10.3390/ijms23042122
Chicago/Turabian StyleGrochecki, Pawel, Irena Smaga, Marta Marszalek-Grabska, Malgorzata Lopatynska-Mazurek, Tymoteusz Slowik, Ewa Gibula-Tarlowska, Ewa Kedzierska, Joanna Listos, Malgorzata Filip, and Jolanta H. Kotlinska. 2022. "Alteration of Ethanol Reward by Prior Mephedrone Exposure: The Role of Age and Matrix Metalloproteinase-9 (MMP-9)" International Journal of Molecular Sciences 23, no. 4: 2122. https://doi.org/10.3390/ijms23042122