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Volume 23
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Review

The Effects of Antioxidants from Natural Products on Obesity, Dyslipidemia, Diabetes and Their Molecular Signaling Mechanism

by
Chindiana Khutami
1,
Sri Adi Sumiwi
1,
Nur Kusaira Khairul Ikram
2,3 and
Muchtaridi Muchtaridi
4,*
1
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang KM 21, Sumedang 45363, Indonesia
2
Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia
3
Centre for Research in Biotechnology for Agriculture (CEBAR), Kuala Lumpur 50603, Malaysia
4
Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang KM 21, Sumedang 45363, Indonesia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(4), 2056; https://doi.org/10.3390/ijms23042056
Submission received: 7 January 2022 / Revised: 6 February 2022 / Accepted: 10 February 2022 / Published: 12 February 2022
(This article belongs to the Special Issue Health Properties of Plant Bioactive Compounds: Immune, Antioxidant and Metabolic Effects)
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Abstract

Obesity is a risk factor that leads to the development of other diseases such as dyslipidemia and diabetes. These three metabolic disorders can occur simultaneously, hence, the treatment requires many drugs. Antioxidant compounds have been reported to have activities against obesity, dyslipidemia and diabetes via several mechanisms. This review aims to discuss the antioxidant compounds that have activity against obesity, dyslipidemia and diabetes together with their molecular signaling mechanism. The literature discussed in this review was obtained from the PUBMED database. Based on the collection of literature obtained, antioxidant compounds having activity against the three disorders (obesity, dyslipidemia and diabetes) were identified. The activity is supported by various molecular signaling pathways that are influenced by these antioxidant compounds, further study of which would be useful in predicting drug targets for a more optimal effect. This review provides insights on utilizing one of these antioxidant compounds as opposed to several drugs. It is hoped that in the future, the number of drugs in treating obesity, dyslipidemia and diabetes altogether can be minimized consequently reducing the risk of side effects.
Keywords: obesity; oxidative stress; dyslipidemia; diabetes; antioxidant obesity; oxidative stress; dyslipidemia; diabetes; antioxidant
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MDPI and ACS Style

Khutami, C.; Sumiwi, S.A.; Khairul Ikram, N.K.; Muchtaridi, M. The Effects of Antioxidants from Natural Products on Obesity, Dyslipidemia, Diabetes and Their Molecular Signaling Mechanism. Int. J. Mol. Sci. 2022, 23, 2056. https://doi.org/10.3390/ijms23042056

AMA Style

Khutami C, Sumiwi SA, Khairul Ikram NK, Muchtaridi M. The Effects of Antioxidants from Natural Products on Obesity, Dyslipidemia, Diabetes and Their Molecular Signaling Mechanism. International Journal of Molecular Sciences. 2022; 23(4):2056. https://doi.org/10.3390/ijms23042056

Chicago/Turabian Style

Khutami, Chindiana, Sri Adi Sumiwi, Nur Kusaira Khairul Ikram, and Muchtaridi Muchtaridi. 2022. "The Effects of Antioxidants from Natural Products on Obesity, Dyslipidemia, Diabetes and Their Molecular Signaling Mechanism" International Journal of Molecular Sciences 23, no. 4: 2056. https://doi.org/10.3390/ijms23042056

APA Style

Khutami, C., Sumiwi, S. A., Khairul Ikram, N. K., & Muchtaridi, M. (2022). The Effects of Antioxidants from Natural Products on Obesity, Dyslipidemia, Diabetes and Their Molecular Signaling Mechanism. International Journal of Molecular Sciences, 23(4), 2056. https://doi.org/10.3390/ijms23042056

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