Emerging Connections between Nuclear Pore Complex Homeostasis and ALS
Abstract
:1. Introduction to Amyotrophic Lateral Sclerosis: Background of Genotypic and Pathological Features
2. Nuclear Transport and NE Quality Control in ALS
2.1. The Soluble Nuclear Transport Machinery Is Impacted in ALS
2.2. NPC Injury in C9-ALS
2.3. How Are Nups Selectively Removed from the NPC?
2.4. NE-Specific Quality Control Mechanisms
2.5. CHMP7 as a Key Player in NPC Injury in ALS
2.6. What Are the Mechanisms That Trigger CHMP7 Nuclear Accumulation and Ensuing NPC Injury?
3. Conclusions
Funding
Conflicts of Interest
References
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Chandra, S.; Lusk, C.P. Emerging Connections between Nuclear Pore Complex Homeostasis and ALS. Int. J. Mol. Sci. 2022, 23, 1329. https://doi.org/10.3390/ijms23031329
Chandra S, Lusk CP. Emerging Connections between Nuclear Pore Complex Homeostasis and ALS. International Journal of Molecular Sciences. 2022; 23(3):1329. https://doi.org/10.3390/ijms23031329
Chicago/Turabian StyleChandra, Sunandini, and C. Patrick Lusk. 2022. "Emerging Connections between Nuclear Pore Complex Homeostasis and ALS" International Journal of Molecular Sciences 23, no. 3: 1329. https://doi.org/10.3390/ijms23031329