Next Article in Journal
A Systematic Review of Circulatory microRNAs in Major Depressive Disorder: Potential Biomarkers for Disease Prognosis
Next Article in Special Issue
Impact of Collagen Crosslinking on Dislocated Human Shoulder Capsules—Effect on Structural and Mechanical Properties
Previous Article in Journal
Apoptosis during ZIKA Virus Infection: Too Soon or Too Late?
Previous Article in Special Issue
Molecular Evolution of Tubulins in Diatoms
Review

Cell Cycle-Dependent Transcription: The Cyclin Dependent Kinase Cdk1 Is a Direct Regulator of Basal Transcription Machineries

by 1,2,3,* and 1,4,*
1
Section for Biochemistry and Molecular Biology, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316 Oslo, Norway
2
Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, 0379 Oslo, Norway
3
Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway
4
Department of Microbiology, Oslo University Hospital, 0372 Oslo, Norway
*
Authors to whom correspondence should be addressed.
Academic Editors: Antonio Mas López and Salah-Eddine Stiriba
Int. J. Mol. Sci. 2022, 23(3), 1293; https://doi.org/10.3390/ijms23031293
Received: 31 December 2021 / Revised: 22 January 2022 / Accepted: 22 January 2022 / Published: 24 January 2022
(This article belongs to the Collection Feature Papers in Macromolecules)
The cyclin-dependent kinase Cdk1 is best known for its function as master regulator of the cell cycle. It phosphorylates several key proteins to control progression through the different phases of the cell cycle. However, studies conducted several decades ago with mammalian cells revealed that Cdk1 also directly regulates the basal transcription machinery, most notably RNA polymerase II. More recent studies in the budding yeast Saccharomyces cerevisiae have revisited this function of Cdk1 and also revealed that Cdk1 directly controls RNA polymerase III activity. These studies have also provided novel insight into the physiological relevance of this process. For instance, cell cycle-stage-dependent activity of these complexes may be important for meeting the increased demand for various proteins involved in housekeeping, metabolism, and protein synthesis. Recent work also indicates that direct regulation of the RNA polymerase II machinery promotes cell cycle entry. Here, we provide an overview of the regulation of basal transcription by Cdk1, and we hypothesize that the original function of the primordial cell-cycle CDK was to regulate RNAPII and that it later evolved into specialized kinases that govern various aspects of the transcription machinery and the cell cycle. View Full-Text
Keywords: cyclin-dependent kinase; Cdk1; RNA polymerase; transcription; cell cycle cyclin-dependent kinase; Cdk1; RNA polymerase; transcription; cell cycle
Show Figures

Figure 1

MDPI and ACS Style

Enserink, J.M.; Chymkowitch, P. Cell Cycle-Dependent Transcription: The Cyclin Dependent Kinase Cdk1 Is a Direct Regulator of Basal Transcription Machineries. Int. J. Mol. Sci. 2022, 23, 1293. https://doi.org/10.3390/ijms23031293

AMA Style

Enserink JM, Chymkowitch P. Cell Cycle-Dependent Transcription: The Cyclin Dependent Kinase Cdk1 Is a Direct Regulator of Basal Transcription Machineries. International Journal of Molecular Sciences. 2022; 23(3):1293. https://doi.org/10.3390/ijms23031293

Chicago/Turabian Style

Enserink, Jorrit M., and Pierre Chymkowitch. 2022. "Cell Cycle-Dependent Transcription: The Cyclin Dependent Kinase Cdk1 Is a Direct Regulator of Basal Transcription Machineries" International Journal of Molecular Sciences 23, no. 3: 1293. https://doi.org/10.3390/ijms23031293

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop