Multifunctional Scaffolds Based on Emulsion and Coaxial Electrospinning Incorporation of Hydroxyapatite for Bone Tissue Regeneration
Abstract
:1. Introduction
2. Hydroxyapatite for Tissue Regeneration and Drug Delivery
3. Multifunctional Scaffolds
3.1. Biopolymers and Synthetic Polymers
3.2. Surface Functionalization
3.3. Incorporation of Functional Compounds
4. Electrospinning
4.1. Coaxial Electrospinning
4.2. Emulsion Electrospinning
5. Recent Developments on Multifunctional Electrospun Scaffolds Incorporating HAp
Multifunctional Composite | Applications/Effects | Ref. |
---|---|---|
PLA, osteogenonTM (ossein, HAp), osteocalcin, Col I | Hydrogel for cartilage reparation. The mineralization and cell adhesion enhanced. | [231] |
PLLA, Col, HAp | Reparation of bone periosteum. Improve tensile properties and mimic the nanoscale structure of the extracellular matrix. | [233] |
PCL, polyurethane, nanoHAp | Promotion of bone regeneration. Controlled degradation and cell ingrowth. | [237] |
PLLA, HAp, dopamine, PPy, Ag | This showed long-term antibacterial, bioactivity, and osteoconductivity properties. | [238] |
PLA, HAp, PCL, BMP-2 | Bone tissue engineering by slower degradation, acid neutralization, and the enhancement of the mesenquimal cell attachment and osteogenic differentiation. | [239] |
PCL, Gel, poloxamer 188, β-lactoglobulin, vitamin K12 | The scaffold provides anti-thrombotic, anti-inflammatory, and cytoprotective activities | [241] |
Silk fibroin, HAp, | Biocompatibility and good mechanical performance. Bone-like architecture. | [243] |
Silk fibroin, CA | Employed for bone implants. | [247] |
CA, silk fibroin, PEO, Hap, BMF-2 | Improve mechanical properties. Promotion of osteogenic differentiation. | [249] |
PVP, ethylcellulose, Au NPs | Bone tissue regeneration. The porosity, mechanical performance, biocompatibility, and osteogenic activity was enhanced. | [250] |
PCL, Gel, heparin, VEGF | Hydrogel with angioactive molecules and hemocompatible surface. | [253] |
PVA, PCL, oregano oil, silica, HAp | Provide antioxidant, anti-inflammatory, and antibacterial properties. | [254] |
PLGA, HAp, Col, amoxicillin | Promote fibroblast, bone growth, and wound healing. | [260] |
6. Perspective and Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Elyaderani, A.K.; De Lama-Odría, M.d.C.; Valle, L.J.d.; Puiggalí, J. Multifunctional Scaffolds Based on Emulsion and Coaxial Electrospinning Incorporation of Hydroxyapatite for Bone Tissue Regeneration. Int. J. Mol. Sci. 2022, 23, 15016. https://doi.org/10.3390/ijms232315016
Elyaderani AK, De Lama-Odría MdC, Valle LJd, Puiggalí J. Multifunctional Scaffolds Based on Emulsion and Coaxial Electrospinning Incorporation of Hydroxyapatite for Bone Tissue Regeneration. International Journal of Molecular Sciences. 2022; 23(23):15016. https://doi.org/10.3390/ijms232315016
Chicago/Turabian StyleElyaderani, Amirmajid Kadkhodaie, María del Carmen De Lama-Odría, Luis J. del Valle, and Jordi Puiggalí. 2022. "Multifunctional Scaffolds Based on Emulsion and Coaxial Electrospinning Incorporation of Hydroxyapatite for Bone Tissue Regeneration" International Journal of Molecular Sciences 23, no. 23: 15016. https://doi.org/10.3390/ijms232315016