Purinergic Receptors P2X7 and P2X4 as Markers of Disease Progression in the rd10 Mouse Model of Inherited Retinal Dystrophy
Abstract
:1. Introduction
2. Results
2.1. Retinal Function in rd10 Mice
2.2. P2X7R Expression in rd10 Mice
2.3. P2X4R Expression in rd10 Mice
2.4. CD11b-Positive Cells in Degenerating Retinas Overexpress P2X7R but Not P2X4R
2.5. P2X7R and P2X4R Expression Levels Vary in Subsets of CD11b-Positive Cells
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Electroretinography
4.3. Optomotor Test
4.4. Immunohistochemistry
4.5. Flow Cytometry
4.6. Western Blotting
4.7. Statistical Analysis
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Martínez-Gil, N.; Kutsyr, O.; Noailles, A.; Fernández-Sánchez, L.; Vidal, L.; Sánchez-Sáez, X.; Sánchez-Castillo, C.; Lax, P.; Cuenca, N.; García, A.G.; et al. Purinergic Receptors P2X7 and P2X4 as Markers of Disease Progression in the rd10 Mouse Model of Inherited Retinal Dystrophy. Int. J. Mol. Sci. 2022, 23, 14758. https://doi.org/10.3390/ijms232314758
Martínez-Gil N, Kutsyr O, Noailles A, Fernández-Sánchez L, Vidal L, Sánchez-Sáez X, Sánchez-Castillo C, Lax P, Cuenca N, García AG, et al. Purinergic Receptors P2X7 and P2X4 as Markers of Disease Progression in the rd10 Mouse Model of Inherited Retinal Dystrophy. International Journal of Molecular Sciences. 2022; 23(23):14758. https://doi.org/10.3390/ijms232314758
Chicago/Turabian StyleMartínez-Gil, Natalia, Oksana Kutsyr, Agustina Noailles, Laura Fernández-Sánchez, Lorena Vidal, Xavier Sánchez-Sáez, Carla Sánchez-Castillo, Pedro Lax, Nicolás Cuenca, Antonio G. García, and et al. 2022. "Purinergic Receptors P2X7 and P2X4 as Markers of Disease Progression in the rd10 Mouse Model of Inherited Retinal Dystrophy" International Journal of Molecular Sciences 23, no. 23: 14758. https://doi.org/10.3390/ijms232314758