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Article

The rs1883832 Polymorphism (CD40-1C>T) Affects the Intensity of IgA Responses after BNT162b2 Vaccination

by
Matthaios Speletas
1,*,
Evangelos Bakaros
1,
Athanasia-Marina Peristeri
2,
Ioanna Voulgaridi
2,
Styliani Sarrou
1,
Vassiliki Paliatsa
1,
Asimina Nasika
2,
Maria Tseroni
3,
Lemonia Anagnostopoulos
2,
Kalliopi Theodoridou
4,
Fani Kalala
1,
Aikaterini Theodoridou
1,
Barbara A. Mouchtouri
2,
Sotirios Tsiodras
5,
Hermann Eibel
6,7 and
Christos Hadjichristodoulou
2,*
1
Department of Immunology & Histocompatibility, Faculty of Medicine, University of Thessaly, 41500 Larissa, Greece
2
Laboratory of Hygiene and Epidemiology, Faculty of Medicine, University of Thessaly, 41222 Larissa, Greece
3
National Public Health Organization, 15123 Athens, Greece
4
Department of Microbiology, Andreas Sygros Hospital, National and Kapodistrian University of Athens, 16121 Athens, Greece
5
Fourth Department of Internal Medicine, School of Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece
6
Department of Rheumatology and Clinical Immunology, Medical Center and Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
7
Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(22), 14056; https://doi.org/10.3390/ijms232214056
Submission received: 19 September 2022 / Revised: 10 November 2022 / Accepted: 12 November 2022 / Published: 14 November 2022
(This article belongs to the Special Issue The Pathway of Antigen Processing and Presentation)
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Abstract

The effectiveness of coronavirus disease 2019 (COVID-19) vaccination strategies is affected by several factors, including the genetic background of the host. In our study, we evaluated the contribution of the functional polymorphism rs1883832 affecting the Kozak sequence of the TNFSF5 gene (c.-1C>T), encoding CD40, to humoral immune responses after vaccination with the spike protein of SARS-CoV-2. The rs1883832 polymorphism was analyzed by PCR-RFLP in 476 individuals (male/female: 216/260, median age: 55.0 years, range: 20–105) of whom 342 received the BNT162b2 mRNA vaccine and 134 received the adenovirus-based vector vaccines (67 on ChAdOx1-nCoV-19 vaccine, 67 on Ad.26.COV2.S vaccine). The IgG and IgA responses were evaluated with chemiluminescent microparticle and ELISA assays on days 21, 42, and 90 after the first dose. The T allele of the rs1883832 polymorphism (allele frequency: 32.8%) was significantly associated with lower IgA levels and represented, as revealed by multivariable analysis, an independent risk factor for reduced anti-spike protein IgA levels on days 42 and 90 following BNT162b2 mRNA vaccination. Similar to serum anti-spike IgA levels, a trend of lower anti-spike IgA concentrations in saliva was found in individuals with the T allele of rs1883832. Finally, the intensity of IgA and IgG responses on day 42 significantly affected the prevalence of COVID-19 after vaccination. The rs1883832 polymorphism may be used as a molecular predictor of the intensity of anti-spike IgA responses after BNT162b2 mRNA vaccination.
Keywords: CD40; rs1883832; IgA responses; COVID-19 vaccination CD40; rs1883832; IgA responses; COVID-19 vaccination

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MDPI and ACS Style

Speletas, M.; Bakaros, E.; Peristeri, A.-M.; Voulgaridi, I.; Sarrou, S.; Paliatsa, V.; Nasika, A.; Tseroni, M.; Anagnostopoulos, L.; Theodoridou, K.; et al. The rs1883832 Polymorphism (CD40-1C>T) Affects the Intensity of IgA Responses after BNT162b2 Vaccination. Int. J. Mol. Sci. 2022, 23, 14056. https://doi.org/10.3390/ijms232214056

AMA Style

Speletas M, Bakaros E, Peristeri A-M, Voulgaridi I, Sarrou S, Paliatsa V, Nasika A, Tseroni M, Anagnostopoulos L, Theodoridou K, et al. The rs1883832 Polymorphism (CD40-1C>T) Affects the Intensity of IgA Responses after BNT162b2 Vaccination. International Journal of Molecular Sciences. 2022; 23(22):14056. https://doi.org/10.3390/ijms232214056

Chicago/Turabian Style

Speletas, Matthaios, Evangelos Bakaros, Athanasia-Marina Peristeri, Ioanna Voulgaridi, Styliani Sarrou, Vassiliki Paliatsa, Asimina Nasika, Maria Tseroni, Lemonia Anagnostopoulos, Kalliopi Theodoridou, and et al. 2022. "The rs1883832 Polymorphism (CD40-1C>T) Affects the Intensity of IgA Responses after BNT162b2 Vaccination" International Journal of Molecular Sciences 23, no. 22: 14056. https://doi.org/10.3390/ijms232214056

APA Style

Speletas, M., Bakaros, E., Peristeri, A.-M., Voulgaridi, I., Sarrou, S., Paliatsa, V., Nasika, A., Tseroni, M., Anagnostopoulos, L., Theodoridou, K., Kalala, F., Theodoridou, A., Mouchtouri, B. A., Tsiodras, S., Eibel, H., & Hadjichristodoulou, C. (2022). The rs1883832 Polymorphism (CD40-1C>T) Affects the Intensity of IgA Responses after BNT162b2 Vaccination. International Journal of Molecular Sciences, 23(22), 14056. https://doi.org/10.3390/ijms232214056

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