Immune Modulation by Myeloid-Derived Suppressor Cells in Diabetic Kidney Disease
Abstract
:1. Introduction
2. Glomerular Cells Associated with DKD
2.1. Endothelial Cells
2.2. Mesangial Cells
2.3. Podocytes
3. MDSCs
3.1. Origin of MDSCs
3.2. Tumor-Derived Factors
3.3. Inflammatory Cytokines and Growth Factors
3.4. Mechanisms Underlying the Suppressive Effects of MDSCs
3.4.1. Depletion of Nutrients Required by T Cells
3.4.2. Generation of Oxidative Stress
3.4.3. Interference with T-Cell Recruitment and Viability
3.4.4. Proliferation of Treg Cells
3.4.5. Promotion of Pro-Tumorigenic Functions
4. Use of MDSCs in Immunotherapy
5. Sources of MDSCs
6. Characteristics of MDSCs in DKD
6.1. The Distribution of MDSCs in DKD
6.2. The Functions of MDSCs in DKD
6.3. MDSCs Influence T Cell Activities under Hyperglycemic Conditions
7. Immunotherapy with Cytokine-Induced MDSCs Improves DKD in Diabetic Mice
8. Conclusions and Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Tumor-Derived Factors | Type of Cancer or Tissue Cells | MDSC Population | Refs |
---|---|---|---|
GM-CSF | Melanoma (human) | + | [59] |
VEGF | Mammary carcinoma (mouse) | + | [60] |
IL-1β | Mammary carcinoma (mouse) | + | [61] |
IL-6 | Fibrosarcoma (mouse) | + | [62] |
Hepatic carcinoma (mouse) | + | [63] | |
Prostate carcinoma (mouse) | + | [64] | |
Esophageal carcinoma (human) | + | [65] | |
TGF-β | Mammary carcinoma (mouse) | + | [66] |
IFN-γ | Lymphoma (mouse) | + | [67] |
PGE2 | Ovarian carcinoma (human) | + | [68] |
Lung carcinoma (mouse) | + | [69] | |
Melanoma (human) | + | [70] | |
Hsp72 | Lung carcinoma (human) | + | [71] |
Colon carcinoma (mouse) | + | ||
Flt3 ligand | Mammary carcinoma (mouse) | + | [72] |
C5a | Lung carcinoma (mouse) | + | [58] |
ATRA | Cervical carcinoma (human) | − | [73] |
Renal carcinoma (human) | − | [74] | |
S100A9 and S100A8 | Myelodysplastic syndromes (mouse) | + | [75] |
Mammary carcinoma (mouse) | + | [76] | |
SCF | Colon carcinoma (mouse) | + | [77] |
Growth factors and cytokines | |||
GM-CSF | ND | + | [78] |
G-CSF | ND | + | [79] |
IL-6 | Hepatic stellate cells | + | [80] |
Poly(I:C) | ND | + | [81] |
C3 | Hepatic stellate cells | + | [82] |
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Hsieh, C.-C.; Chang, C.-C.; Hsu, Y.-C.; Lin, C.-L. Immune Modulation by Myeloid-Derived Suppressor Cells in Diabetic Kidney Disease. Int. J. Mol. Sci. 2022, 23, 13263. https://doi.org/10.3390/ijms232113263
Hsieh C-C, Chang C-C, Hsu Y-C, Lin C-L. Immune Modulation by Myeloid-Derived Suppressor Cells in Diabetic Kidney Disease. International Journal of Molecular Sciences. 2022; 23(21):13263. https://doi.org/10.3390/ijms232113263
Chicago/Turabian StyleHsieh, Ching-Chuan, Cheng-Chih Chang, Yung-Chien Hsu, and Chun-Liang Lin. 2022. "Immune Modulation by Myeloid-Derived Suppressor Cells in Diabetic Kidney Disease" International Journal of Molecular Sciences 23, no. 21: 13263. https://doi.org/10.3390/ijms232113263