MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases
Abstract
:1. Introduction
2. What Are Mitochondrial Derived Peptides (MDPs)?
2.1. MOTS-c: Origin, History, and Structure
2.2. Molecular Mechanisms and Pathways of MOTS-C
2.3. Aging and Longevity: MOTS-c
2.4. Age-Related Diseases: MOTS-c
2.4.1. Diabetes
2.4.2. Cardiovascular Diseases
2.4.3. Post-Menopausal Disorders
2.4.4. Osteoporosis
2.4.5. Alzheimer’s Disease
2.5. MOTS-c in Relation to Muscle Homeostasis and Physical Activity
3. Future Implications
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Mohtashami, Z.; Singh, M.K.; Salimiaghdam, N.; Ozgul, M.; Kenney, M.C. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. Int. J. Mol. Sci. 2022, 23, 11991. https://doi.org/10.3390/ijms231911991
Mohtashami Z, Singh MK, Salimiaghdam N, Ozgul M, Kenney MC. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. International Journal of Molecular Sciences. 2022; 23(19):11991. https://doi.org/10.3390/ijms231911991
Chicago/Turabian StyleMohtashami, Zahra, Mithalesh K. Singh, Nasim Salimiaghdam, Mustafa Ozgul, and M. Cristina Kenney. 2022. "MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases" International Journal of Molecular Sciences 23, no. 19: 11991. https://doi.org/10.3390/ijms231911991