Spontaneous Occurrence of Various Types of Hepatocellular Adenoma in the Livers of Metabolic Syndrome-Associated Steatohepatitis Model TSOD Mice
Abstract
:1. Introduction
1.1. HNF1α-Inactivated HCA (H-HCA)
1.2. Inflammatory HCA (IHCA)
1.3. β-Catenin-Activated HCA (b-HCA)
1.4. β-Catenin-Activated IHCA (b-IHCA)
2. Results
2.1. Frequency of Liver Tumor
2.2. Characteristic Histopathological and Immunohistochemical Findings of GS-Positive Liver Tumors
2.3. Characteristics of GS-Negative Liver Tumors
2.3.1. HNF1a-Inactivated HCA Tumor Mimics
2.3.2. Inflammatory HCA Tumor Mimics
2.3.3. Both HNF1 α-Inactivated HCA and Inflammatory HCA Tumor Mimic
2.3.4. B-Catenin-Activated IHCA (B-IHCA) Tumor Mimic
3. Materials and Methods
4. Conclusions
4.1. Investigation of the Molecular Biological Features and Microenvironmental Differences Underlying the Development of HCA Subtypes
4.2. Investigation of Carcinogenic Mechanism for HCA
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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No | Diameter | GS | L-FABP | SAA | β-Catenin |
---|---|---|---|---|---|
1 | 7 mm | Negative | Reduced | Positive | Membrane |
2 | 14 mm | Negative | Positive | Positive | Membrane |
3 | 6 mm | Negative | Reduced | Negative | Membrane |
4 | 7 mm | Negative | Positive | Negative | Membrane |
5 | 3 mm | Negative | Reduced | Negative | Membrane |
6: Major | 15 mm | Negative | Positive | Positive | Membrane |
6: focal | 2 mm × 2 | Positive | Positive | Negative | Nucleus |
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Shao, W.; Jargalsaikhan, O.; Ichimura-Shimizu, M.; Cai, Q.; Ogawa, H.; Miyakami, Y.; Atsumi, K.; Tomita, M.; Sutoh, M.; Toyohara, S.; et al. Spontaneous Occurrence of Various Types of Hepatocellular Adenoma in the Livers of Metabolic Syndrome-Associated Steatohepatitis Model TSOD Mice. Int. J. Mol. Sci. 2022, 23, 11923. https://doi.org/10.3390/ijms231911923
Shao W, Jargalsaikhan O, Ichimura-Shimizu M, Cai Q, Ogawa H, Miyakami Y, Atsumi K, Tomita M, Sutoh M, Toyohara S, et al. Spontaneous Occurrence of Various Types of Hepatocellular Adenoma in the Livers of Metabolic Syndrome-Associated Steatohepatitis Model TSOD Mice. International Journal of Molecular Sciences. 2022; 23(19):11923. https://doi.org/10.3390/ijms231911923
Chicago/Turabian StyleShao, Wenhua, Orgil Jargalsaikhan, Mayuko Ichimura-Shimizu, Qinyi Cai, Hirohisa Ogawa, Yuko Miyakami, Kengo Atsumi, Mitsuru Tomita, Mitsuko Sutoh, Shunji Toyohara, and et al. 2022. "Spontaneous Occurrence of Various Types of Hepatocellular Adenoma in the Livers of Metabolic Syndrome-Associated Steatohepatitis Model TSOD Mice" International Journal of Molecular Sciences 23, no. 19: 11923. https://doi.org/10.3390/ijms231911923