Amyloid Aβ25-35 Aggregates Say ‘NO’ to Long-Term Potentiation in the Hippocampus through Activation of Stress-Induced Phosphatase 1 and Mitochondrial Na+/Ca2+ Exchanger
Abstract
:1. Introduction
2. Results
2.1. Aβ25-35 Aggregates Impaired Synaptic Plasticity through PP1/PP2A-Sensitive Mechanism
2.2. PP2B Is Not Involved in the Aβ25-35-Dependent Deteriorations of Synaptic Plasticity
2.3. Direct Measurements of STPP Activity in Hippocampal Slices
2.4. Delayed Enzyme Blockade Protocol for STPP Influence on Synaptic Transmission
2.5. Which Phosphatase(s) Is Involved in OA-Associated Attenuation of Aβ25-35-Induced LTP Suppression?
2.6. Mitochondria and Aβ25-35 Aggregates
2.7. Aβ25-35 Aggregates ‘Say’ NO to the LTP in CA3–CA1 Synapses
3. Discussion
4. Materials and Methods
4.1. Hippocampal Slice Preparation
4.2. Electrophysiology
4.3. NO Imaging of Hippocampal Slices
4.4. Phosphatase Assay
4.5. Isolation and Purification of Mitochondria
4.6. Ca2+-Dependent Swelling of Mitochondria
4.7. ROS Detection
4.8. Measurements of the Mitochondrial Transmembrane Potential, ΔΨm
4.9. Drugs
4.10. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
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Maltsev, A.V.; Nikiforova, A.B.; Bal, N.V.; Balaban, P.M. Amyloid Aβ25-35 Aggregates Say ‘NO’ to Long-Term Potentiation in the Hippocampus through Activation of Stress-Induced Phosphatase 1 and Mitochondrial Na+/Ca2+ Exchanger. Int. J. Mol. Sci. 2022, 23, 11848. https://doi.org/10.3390/ijms231911848
Maltsev AV, Nikiforova AB, Bal NV, Balaban PM. Amyloid Aβ25-35 Aggregates Say ‘NO’ to Long-Term Potentiation in the Hippocampus through Activation of Stress-Induced Phosphatase 1 and Mitochondrial Na+/Ca2+ Exchanger. International Journal of Molecular Sciences. 2022; 23(19):11848. https://doi.org/10.3390/ijms231911848
Chicago/Turabian StyleMaltsev, Alexander V., Anna B. Nikiforova, Natalia V. Bal, and Pavel M. Balaban. 2022. "Amyloid Aβ25-35 Aggregates Say ‘NO’ to Long-Term Potentiation in the Hippocampus through Activation of Stress-Induced Phosphatase 1 and Mitochondrial Na+/Ca2+ Exchanger" International Journal of Molecular Sciences 23, no. 19: 11848. https://doi.org/10.3390/ijms231911848