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Article

Lipophilic Compounds and Antibacterial Activity of Opuntia ficus-indica Root Extracts from Algeria

1
Département de Biologie Physico-Chimique, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia 06000, Algeria
2
CICECO—Aveiro Institute of Materials and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
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Département des Sciences Alimentaires, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia 06000, Algeria
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Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia 06000, Algeria
*
Author to whom correspondence should be addressed.
Academic Editor: Giulio Vistoli
Int. J. Mol. Sci. 2022, 23(19), 11161; https://doi.org/10.3390/ijms231911161
Received: 1 August 2022 / Revised: 8 September 2022 / Accepted: 16 September 2022 / Published: 22 September 2022
(This article belongs to the Section Bioactives and Nutraceuticals)
The chemical composition, investigated by gas chromatography-mass spectrometry, and antibacterial activity of lipophilic extractives of three varieties of Opuntia ficus-indica roots from Algeria are reported in this paper for the first time. The results obtained revealed a total of 55 compounds, including fatty acids, sterols, monoglycerides and long chain aliphatic alcohols that were identified and quantified. β-Sitosterol was found as the major compound of the roots of the three varieties. Furthermore, considerable amounts of essential fatty acids (ω3, ω6, and ω9) such as oleic, linoleic, and linolenic acids were also identified. The green variety was the richest among the three studied varieties. The antibacterial activity, evaluated with disc diffusion method, revealed that lipophilic extracts were effective mainly against Gram-positive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) (19~23 mm). Gram-negative strains mainly Pseudomonas aeruginosa gave an inhibition zone of 18 mm, which is considered high antibacterial activity. The minimal inhibitory concentrations of the tested bacteria revealed interesting values against the majority of bacteria tested: 75–100 µg mL−1 for Bacillus sp., 250–350 µg/mL for the two Staphylococcus strains, 550–600 µg mL−1 for E. coli, and 750–950 µg mL−1 obtained with Pseudomonas sp. This study allows us to conclude that the lipophilic fractions of cactus roots possess interesting phytochemicals such as steroids, some fatty acids and long chain alcohols that acted as antibiotic-like compounds countering pathogenic strains. View Full-Text
Keywords: antibacterial activity; fatty acids; MIC; Opuntia ficus-indica; roots lipophilic extracts; sterols antibacterial activity; fatty acids; MIC; Opuntia ficus-indica; roots lipophilic extracts; sterols
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MDPI and ACS Style

Benramdane, E.; Chougui, N.; Ramos, P.A.B.; Makhloufi, N.; Tamendjari, A.; Silvestre, A.J.D.; Santos, S.A.O. Lipophilic Compounds and Antibacterial Activity of Opuntia ficus-indica Root Extracts from Algeria. Int. J. Mol. Sci. 2022, 23, 11161. https://doi.org/10.3390/ijms231911161

AMA Style

Benramdane E, Chougui N, Ramos PAB, Makhloufi N, Tamendjari A, Silvestre AJD, Santos SAO. Lipophilic Compounds and Antibacterial Activity of Opuntia ficus-indica Root Extracts from Algeria. International Journal of Molecular Sciences. 2022; 23(19):11161. https://doi.org/10.3390/ijms231911161

Chicago/Turabian Style

Benramdane, Elias, Nadia Chougui, Patrícia A. B. Ramos, Nawal Makhloufi, Abderezak Tamendjari, Armando J. D. Silvestre, and Sónia A. O. Santos. 2022. "Lipophilic Compounds and Antibacterial Activity of Opuntia ficus-indica Root Extracts from Algeria" International Journal of Molecular Sciences 23, no. 19: 11161. https://doi.org/10.3390/ijms231911161

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