Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to Phenotype
Abstract
:1. Introduction
2. Mouse DC Subsets
3. Human DC Subsets
4. Phenotype Changes of DCs Based on the Infective Agents
5. DC Activation
6. DCs in CRSsNP
7. DCs in CRSwNP
8. Future Prospect of DCs as a Potential Therapeutic Target for CRS
9. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
DCs | dendritic cells |
Th | T helper |
Th1 | type 1 T helper |
Th2 | type 2 T helper |
Th17 | type 17 T helper |
CRS | interleukin |
CRSsNP | CRS without NPs |
CRSwNP | CRS with NPs |
XCR | XC chemokine receptor |
BATF | basic leucine zipper ATF-like transcription factor |
MHC | major histocompatibility complex |
SIRPα | signal-regulatory protein alpha |
ZEB | zinc finger E box binding homeobox |
Siglec-H | sialic acid-binding immunoglobulin-like lectin-H |
IFN | interferon |
TLR | toll-like receptor |
inf-DC | inflammatory DC |
MoDC | monocyte-derived DC |
pDC | plasmacytoid DC |
cDC | conventional DC |
BDCA | blood dendritic cell antigen |
LC | langerhans cell |
GM-CSF | granulocyte-macrophage colony stimulating factor |
Flt3L | FMS-like tyrosine kinase 3 ligand |
IL | interleukin |
CCL20 | chemokine ligand 20 |
OPN | osteopontin |
CCR7 | C-C chemokine receptor type 7 |
CXCL8 | C-X-C Motif Chemokine Ligand 8 |
OSM | oncostatin M |
NPs | nasal polyps |
OX40L | OX40 ligand |
PD-L1 | programmed death ligand-1 |
TSLP | thymic stromal lymphopoietin |
VD3 | vitamin D3 |
References
- Gardner, A.; de Mingo Pulido, Á.; Ruffell, B. Dendritic Cells and Their Role in Immunotherapy. Front. Immunol. 2020, 11, 924. [Google Scholar] [CrossRef] [PubMed]
- Yin, X.; Chen, S.; Eisenbarth, S.C. Dendritic Cell Regulation of T Helper Cells. Annu. Rev. Immunol. 2021, 39, 759–790. [Google Scholar] [CrossRef] [PubMed]
- Gaurav, R.; Agrawal, D.K. Clinical view on the importance of dendritic cells in asthma. Expert Rev. Clin. Immunol. 2013, 9, 899–919. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Melum, G.R.; Farkas, L.; Scheel, C.; Van Dieren, B.; Gran, E.; Liu, Y.J.; Johansen, F.E.; Jahnsen, F.L.; Baekkevold, E.S. A thymic stromal lymphopoietin-responsive dendritic cell subset mediates allergic responses in the upper airway mucosa. J. Allergy Clin. Immunol. 2014, 134, 613–621.e7. [Google Scholar] [CrossRef] [Green Version]
- Giavina-Bianchi, P.; Aun, M.V.; Takejima, P.; Kalil, J.; Agondi, R.C. United airway disease: Current perspectives. J. Asthma Allergy 2016, 9, 93–100. [Google Scholar] [CrossRef] [Green Version]
- Cho, S.H.; Hamilos, D.L.; Han, D.H.; Laidlaw, T.M. Phenotypes of Chronic Rhinosinusitis. J. Allergy Clin. Immunol. Pract. 2020, 8, 1505–1511. [Google Scholar] [CrossRef]
- Stevens, W.W.; Schleimer, R.P.; Kern, R.C. Chronic Rhinosinusitis with Nasal Polyps. J. Allergy Clin. Immunol. Pract. 2016, 4, 565–572. [Google Scholar] [CrossRef] [Green Version]
- Eifan, A.O.; Durham, S.R. Pathogenesis of rhinitis. Clin. Exp. Allergy J. Br. Soc. Allergy Clin. Immunol. 2016, 46, 1139–1151. [Google Scholar] [CrossRef]
- Pezato, R.; Pérez-Novo, C.A.; Holtappels, G.; De Ruyck, N.; Van Crombruggen, K.; De Vos, G.; Bachert, C.; Derycke, L. The expression of dendritic cell subsets in severe chronic rhinosinusitis with nasal polyps is altered. Immunobiology 2014, 219, 729–736. [Google Scholar] [CrossRef]
- Poposki, J.A.; Peterson, S.; Welch, K.; Schleimer, R.P.; Hulse, K.E.; Peters, A.T.; Norton, J.; Suh, L.A.; Carter, R.; Harris, K.E.; et al. Elevated presence of myeloid dendritic cells in nasal polyps of patients with chronic rhinosinusitis. Clin. Exp. Allergy J. Br. Soc. Allergy Clin. Immunol. 2015, 45, 384–393. [Google Scholar] [CrossRef] [Green Version]
- Guilliams, M.; Ginhoux, F.; Jakubzick, C.; Naik, S.H.; Onai, N.; Schraml, B.U.; Segura, E.; Tussiwand, R.; Yona, S. Dendritic cells, monocytes and macrophages: A unified nomenclature based on ontogeny. Nat. Rev. Immunol. 2014, 14, 571–578. [Google Scholar] [CrossRef]
- Wylie, B.; Macri, C.; Mintern, J.D.; Waithman, J. Dendritic Cells and Cancer: From Biology to Therapeutic Intervention. Cancers 2019, 11, 521. [Google Scholar] [CrossRef] [Green Version]
- Crozat, K.; Guiton, R.; Contreras, V.; Feuillet, V.; Dutertre, C.A.; Ventre, E.; Vu Manh, T.P.; Baranek, T.; Storset, A.K.; Marvel, J.; et al. The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8alpha+ dendritic cells. J. Exp. Med. 2010, 207, 1283–1292. [Google Scholar] [CrossRef]
- Bachem, A.; Güttler, S.; Hartung, E.; Ebstein, F.; Schaefer, M.; Tannert, A.; Salama, A.; Movassaghi, K.; Opitz, C.; Mages, H.W.; et al. Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells. J. Exp. Med. 2010, 207, 1273–1281. [Google Scholar] [CrossRef] [Green Version]
- Murphy, T.L.; Grajales-Reyes, G.E.; Wu, X.; Tussiwand, R.; Briseño, C.G.; Iwata, A.; Kretzer, N.M.; Durai, V.; Murphy, K.M. Transcriptional Control of Dendritic Cell Development. Annu. Rev. Immunol. 2016, 34, 93–119. [Google Scholar] [CrossRef] [Green Version]
- Embgenbroich, M.; Burgdorf, S. Current Concepts of Antigen Cross-Presentation. Front. Immunol. 2018, 9, 1643. [Google Scholar] [CrossRef] [Green Version]
- Hochrein, H.; Shortman, K.; Vremec, D.; Scott, B.; Hertzog, P.; O’Keeffe, M. Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets. J. Immunol. (Baltim. Md. 1950) 2001, 166, 5448–5455. [Google Scholar] [CrossRef] [Green Version]
- Spranger, S.; Dai, D.; Horton, B.; Gajewski, T.F. Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy. Cancer Cell 2017, 31, 711–723.e4. [Google Scholar] [CrossRef] [Green Version]
- Guilliams, M.; Dutertre, C.A.; Scott, C.L.; McGovern, N.; Sichien, D.; Chakarov, S.; Van Gassen, S.; Chen, J.; Poidinger, M.; De Prijck, S.; et al. Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species. Immunity 2016, 45, 669–684. [Google Scholar] [CrossRef] [Green Version]
- Scott, C.L.; Soen, B.; Martens, L.; Skrypek, N.; Saelens, W.; Taminau, J.; Blancke, G.; Van Isterdael, G.; Huylebroeck, D.; Haigh, J.; et al. The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2. J. Exp. Med. 2016, 213, 897–911. [Google Scholar] [CrossRef] [Green Version]
- Macri, C.; Pang, E.S.; Patton, T.; O’Keeffe, M. Dendritic cell subsets. Semin. Cell Dev. Biol. 2018, 84, 11–21. [Google Scholar] [CrossRef]
- Verheye, E.; Bravo Melgar, J.; Deschoemaeker, S.; Raes, G.; Maes, A.; De Bruyne, E.; Menu, E.; Vanderkerken, K.; Laoui, D.; De Veirman, K. Dendritic Cell-Based Immunotherapy in Multiple Myeloma: Challenges, Opportunities, and Future Directions. Int. J. Mol. Sci. 2022, 23, 904. [Google Scholar] [CrossRef]
- Kingston, D.; Schmid, M.A.; Onai, N.; Obata-Onai, A.; Baumjohann, D.; Manz, M.G. The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis. Blood 2009, 114, 835–843. [Google Scholar] [CrossRef]
- Cisse, B.; Caton, M.L.; Lehner, M.; Maeda, T.; Scheu, S.; Locksley, R.; Holmberg, D.; Zweier, C.; den Hollander, N.S.; Kant, S.G.; et al. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell 2008, 135, 37–48. [Google Scholar] [CrossRef] [Green Version]
- Musumeci, A.; Lutz, K.; Winheim, E.; Krug, A.B. What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development and Heterogeneity. Front. Immunol. 2019, 10, 1222. [Google Scholar] [CrossRef] [Green Version]
- Anderson, D.A., 3rd; Dutertre, C.A.; Ginhoux, F.; Murphy, K.M. Genetic models of human and mouse dendritic cell development and function. Nat. Rev. Immunol. 2021, 21, 101–115. [Google Scholar] [CrossRef]
- Zitvogel, L.; Galluzzi, L.; Kepp, O.; Smyth, M.J.; Kroemer, G. Type I interferons in anticancer immunity. Nat. Rev. Immunol. 2015, 15, 405–414. [Google Scholar] [CrossRef]
- Reizis, B.; Bunin, A.; Ghosh, H.S.; Lewis, K.L.; Sisirak, V. Plasmacytoid dendritic cells: Recent progress and open questions. Annu. Rev. Immunol. 2011, 29, 163–183. [Google Scholar] [CrossRef] [Green Version]
- Villadangos, J.A.; Young, L. Antigen-presentation properties of plasmacytoid dendritic cells. Immunity 2008, 29, 352–361. [Google Scholar] [CrossRef] [Green Version]
- León, B.; López-Bravo, M.; Ardavín, C. Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania. Immunity 2007, 26, 519–531. [Google Scholar] [CrossRef] [Green Version]
- Zhan, Y.; Xu, Y.; Seah, S.; Brady, J.L.; Carrington, E.M.; Cheers, C.; Croker, B.A.; Wu, L.; Villadangos, J.A.; Lew, A.M. Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways. J. Immunol. (Baltim. Md. 1950) 2010, 185, 2125–2133. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Segura, E.; Amigorena, S. Inflammatory dendritic cells in mice and humans. Trends Immunol. 2013, 34, 440–445. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Coutant, F. Shaping of Monocyte-Derived Dendritic Cell Development and Function by Environmental Factors in Rheumatoid Arthritis. Int. J. Mol. Sci. 2021, 22, 13670. [Google Scholar] [CrossRef] [PubMed]
- Ballesteros-Tato, A.; León, B.; Lund, F.E.; Randall, T.D. Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8(+) T cell responses to influenza. Nat. Immunol. 2010, 11, 216–224. [Google Scholar] [CrossRef] [Green Version]
- Nakano, H.; Lin, K.L.; Yanagita, M.; Charbonneau, C.; Cook, D.N.; Kakiuchi, T.; Gunn, M.D. Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. Nat. Immunol. 2009, 10, 394–402. [Google Scholar] [CrossRef]
- Collin, M.; Bigley, V. Human dendritic cell subsets: An update. Immunology 2018, 154, 3–20. [Google Scholar] [CrossRef]
- Bao, M.; Liu, Y.J. Regulation of TLR7/9 signaling in plasmacytoid dendritic cells. Protein Cell 2013, 4, 40–52. [Google Scholar] [CrossRef] [Green Version]
- McIlroy, D.; Troadec, C.; Grassi, F.; Samri, A.; Barrou, B.; Autran, B.; Debré, P.; Feuillard, J.; Hosmalin, A. Investigation of human spleen dendritic cell phenotype and distribution reveals evidence of in vivo activation in a subset of organ donors. Blood 2001, 97, 3470–3477. [Google Scholar] [CrossRef]
- Summers, K.L.; Hock, B.D.; McKenzie, J.L.; Hart, D.N. Phenotypic characterization of five dendritic cell subsets in human tonsils. Am. J. Pathol. 2001, 159, 285–295. [Google Scholar] [CrossRef] [Green Version]
- Segura, E.; Valladeau-Guilemond, J.; Donnadieu, M.H.; Sastre-Garau, X.; Soumelis, V.; Amigorena, S. Characterization of resident and migratory dendritic cells in human lymph nodes. J. Exp. Med. 2012, 209, 653–660. [Google Scholar] [CrossRef]
- Perez-Novo, C.; Pezato, R. Dendritic cell subset expression in severe chronic rhinosinusitis with nasal polyps. Curr. Opin. Allergy Clin. Immunol. 2017, 17, 1–4. [Google Scholar] [CrossRef]
- Upham, J.W.; Xi, Y. Dendritic Cells in Human Lung Disease: Recent Advances. Chest 2017, 151, 668–673. [Google Scholar] [CrossRef] [Green Version]
- Guilliams, M.; Lambrecht, B.N.; Hammad, H. Division of labor between lung dendritic cells and macrophages in the defense against pulmonary infections. Mucosal Immunol. 2013, 6, 464–473. [Google Scholar] [CrossRef]
- Kopf, M.; Schneider, C.; Nobs, S.P. The development and function of lung-resident macrophages and dendritic cells. Nat. Immunol. 2015, 16, 36–44. [Google Scholar] [CrossRef]
- Rajesh, A.; Wise, L.; Hibma, M. The role of Langerhans cells in pathologies of the skin. Immunol. Cell Biol. 2019, 97, 700–713. [Google Scholar] [CrossRef]
- Patterson, B.K.; Landay, A.; Siegel, J.N.; Flener, Z.; Pessis, D.; Chaviano, A.; Bailey, R.C. Susceptibility to human immunodeficiency virus-1 infection of human foreskin and cervical tissue grown in explant culture. Am. J. Pathol. 2002, 161, 867–873. [Google Scholar] [CrossRef] [Green Version]
- Valladeau, J.; Ravel, O.; Dezutter-Dambuyant, C.; Moore, K.; Kleijmeer, M.; Liu, Y.; Duvert-Frances, V.; Vincent, C.; Schmitt, D.; Davoust, J.; et al. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 2000, 12, 71–81. [Google Scholar] [CrossRef] [Green Version]
- Li, B.Z.; Ye, Q.L.; Xu, W.D.; Li, J.H.; Ye, D.Q.; Xu, Y. GM-CSF alters dendritic cells in autoimmune diseases. Autoimmunity 2013, 46, 409–418. [Google Scholar] [CrossRef]
- Balan, S.; Saxena, M.; Bhardwaj, N. Dendritic cell subsets and locations. Int. Rev. Cell Mol. Biol. 2019, 348, 1–68. [Google Scholar] [CrossRef]
- Anandasabapathy, N.; Breton, G.; Hurley, A.; Caskey, M.; Trumpfheller, C.; Sarma, P.; Pring, J.; Pack, M.; Buckley, N.; Matei, I.; et al. Efficacy and safety of CDX-301, recombinant human Flt3L, at expanding dendritic cells and hematopoietic stem cells in healthy human volunteers. Bone Marrow Transplant. 2015, 50, 924–930. [Google Scholar] [CrossRef]
- Segura, E.; Touzot, M.; Bohineust, A.; Cappuccio, A.; Chiocchia, G.; Hosmalin, A.; Dalod, M.; Soumelis, V.; Amigorena, S. Human inflammatory dendritic cells induce Th17 cell differentiation. Immunity 2013, 38, 336–348. [Google Scholar] [CrossRef] [Green Version]
- Soruri, A.; Zwirner, J. Dendritic cells: Limited potential in immunotherapy. Int. J. Biochem. Cell Biol. 2005, 37, 241–245. [Google Scholar] [CrossRef]
- Granot, T.; Senda, T.; Carpenter, D.J.; Matsuoka, N.; Weiner, J.; Gordon, C.L.; Miron, M.; Kumar, B.V.; Griesemer, A.; Ho, S.H.; et al. Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life. Immunity 2017, 46, 504–515. [Google Scholar] [CrossRef] [Green Version]
- Rhodes, J.W.; Tong, O.; Harman, A.N.; Turville, S.G. Human Dendritic Cell Subsets, Ontogeny, and Impact on HIV Infection. Front. Immunol. 2019, 10, 1088. [Google Scholar] [CrossRef] [Green Version]
- Sundquist, M.; Wick, M.J. Salmonella induces death of CD8alpha(+) dendritic cells but not CD11c(int)CD11b(+) inflammatory cells in vivo via MyD88 and TNFR1. J. Leukoc. Biol. 2009, 85, 225–234. [Google Scholar] [CrossRef]
- Stegelmeier, A.A.; van Vloten, J.P.; Mould, R.C.; Klafuric, E.M.; Minott, J.A.; Wootton, S.K.; Bridle, B.W.; Karimi, K. Myeloid Cells during Viral Infections and Inflammation. Viruses 2019, 11, 168. [Google Scholar] [CrossRef] [Green Version]
- Davison, A.M.; King, N.J. Accelerated dendritic cell differentiation from migrating Ly6C(lo) bone marrow monocytes in early dermal West Nile virus infection. J. Immunol. 2011, 186, 2382–2396. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Singh, P.; Yao, Y.; Weliver, A.; Broxmeyer, H.E.; Hong, S.C.; Chang, C.H. Vaccinia virus infection modulates the hematopoietic cell compartments in the bone marrow. Stem Cells 2008, 26, 1009–1016. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Zuniga, E.I.; McGavern, D.B.; Pruneda-Paz, J.L.; Teng, C.; Oldstone, M.B. Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection. Nat. Immunol. 2004, 5, 1227–1234. [Google Scholar] [CrossRef] [PubMed]
- Welner, R.S.; Pelayo, R.; Nagai, Y.; Garrett, K.P.; Wuest, T.R.; Carr, D.J.; Borghesi, L.A.; Farrar, M.A.; Kincade, P.W. Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection. Blood 2008, 112, 3753–3761. [Google Scholar] [CrossRef] [PubMed]
- Megías, J.; Yáñez, A.; Moriano, S.; O’Connor, J.E.; Gozalbo, D.; Gil, M.L. Direct Toll-like receptor-mediated stimulation of hematopoietic stem and progenitor cells occurs in vivo and promotes differentiation toward macrophages. Stem Cells 2012, 30, 1486–1495. [Google Scholar] [CrossRef]
- Yáñez, A.; Megías, J.; O’Connor, J.E.; Gozalbo, D.; Gil, M.L. Candida albicans induces selective development of macrophages and monocyte derived dendritic cells by a TLR2 dependent signalling. PLoS ONE 2011, 6, e24761. [Google Scholar] [CrossRef]
- E Sousa, C.R. Activation of dendritic cells: Translating innate into adaptive immunity. Curr. Opin. Immunol. 2004, 16, 21–25. [Google Scholar] [CrossRef]
- Kadowaki, N.; Ho, S.; Antonenko, S.; Malefyt, R.W.; Kastelein, R.A.; Bazan, F.; Liu, Y.J. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J. Exp. Med. 2001, 194, 863–869. [Google Scholar] [CrossRef]
- Sheen, J.H.; Strainic, M.G.; Liu, J.; Zhang, W.; Yi, Z.; Medof, M.E.; Heeger, P.S. TLR-Induced Murine Dendritic Cell (DC) Activation Requires DC-Intrinsic Complement. J. Immunol. (Baltim. Md. 1950) 2017, 199, 278–291. [Google Scholar] [CrossRef] [Green Version]
- Greene, T.T.; Jo, Y.R.; Zuniga, E.I. Infection and cancer suppress pDC derived IFN-I. Curr. Opin. Immunol. 2020, 66, 114–122. [Google Scholar] [CrossRef]
- Zhang, F.; Ren, S.; Zuo, Y. DC-SIGN, DC-SIGNR and LSECtin: C-type lectins for infection. Int. Rev. Immunol. 2014, 33, 54–66. [Google Scholar] [CrossRef]
- Scutera, S.; Riboldi, E.; Daniele, R.; Elia, A.R.; Fraone, T.; Castagnoli, C.; Giovarelli, M.; Musso, T.; Sozzani, S. Production and function of activin A in human dendritic cells. Eur. Cytokine Netw. 2008, 19, 60–68. [Google Scholar] [CrossRef]
- Hara, S.; Nagai-Yoshioka, Y.; Yamasaki, R.; Adachi, Y.; Fujita, Y.; Watanabe, K.; Maki, K.; Nishihara, T.; Ariyoshi, W. Dectin-1-mediated suppression of RANKL-induced osteoclastogenesis by glucan from baker’s yeast. J. Cell. Physiol. 2021, 236, 5098–5107. [Google Scholar] [CrossRef]
- Chen, Y.L.; Gomes, T.; Hardman, C.S.; Braga, F.A.V.; Gutowska-Owsiak, D.; Salimi, M.; Gray, N.; Duncan, D.A.; Reynolds, G.; Johnson, D.; et al. Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation. J. Exp. Med. 2020, 217, e20190811. [Google Scholar] [CrossRef]
- McGreal, E.P.; Miller, J.L.; Gordon, S. Ligand recognition by antigen-presenting cell C-type lectin receptors. Curr. Opin. Immunol. 2005, 17, 18–24. [Google Scholar] [CrossRef]
- Beg, A.A. Endogenous ligands of Toll-like receptors: Implications for regulating inflammatory and immune responses. Trends Immunol. 2002, 23, 509–512. [Google Scholar] [CrossRef]
- Fuertes, M.B.; Domaica, C.I.; Zwirner, N.W. Leveraging NKG2D Ligands in Immuno-Oncology. Front. Immunol. 2021, 12, 713158. [Google Scholar] [CrossRef]
- Gonzalez-Gil, A.; Schnaar, R.L. Siglec Ligands. Cells 2021, 10, 1260. [Google Scholar] [CrossRef]
- O’Connell, B.P.; Schlosser, R.J.; Wentzel, J.L.; Nagel, W.; Mulligan, J.K. Systemic monocyte-derived dendritic cells and associated Th2 skewing in chronic rhinosinusitis. Otolaryngol. Head Neck Surg. 2014, 150, 312–320. [Google Scholar] [CrossRef]
- Husain, Q.; Sedaghat, A.R. Understanding and clinical relevance of chronic rhinosinusitis endotypes. Clin. Otolaryngol. 2019, 44, 887–897. [Google Scholar] [CrossRef]
- Rissoan, M.C.; Soumelis, V.; Kadowaki, N.; Grouard, G.; Briere, F.; de Waal Malefyt, R.; Liu, Y.J. Reciprocal control of T helper cell and dendritic cell differentiation. Science 1999, 283, 1183–1186. [Google Scholar] [CrossRef]
- Kirsche, H.; Niederführ, A.; Deutschle, T.; Fuchs, C.; Riechelmann, H. Ratio of myeloid and plasmacytoid dendritic cells and TH2 skew in CRS with nasal polyps. Allergy 2010, 65, 24–31. [Google Scholar] [CrossRef]
- Ayers, C.M.; Schlosser, R.J.; O’Connell, B.P.; Atkinson, C.; Mulligan, R.M.; Casey, S.E.; Bleier, B.S.; Wang, E.W.; Sansoni, E.R.; Kuhlen, J.L.; et al. Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Int. Forum Allergy Rhinol. 2011, 1, 296–302. [Google Scholar] [CrossRef]
- Holgate, S.T.; Bodey, K.S.; Janezic, A.; Frew, A.J.; Kaplan, A.P.; Teran, L.M. Release of RANTES, MIP-1 alpha, and MCP-1 into asthmatic airways following endobronchial allergen challenge. Am. J. Respir. Crit. Care Med. 1997, 156, 1377–1383. [Google Scholar] [CrossRef]
- Gu, L.; Tseng, S.; Horner, R.M.; Tam, C.; Loda, M.; Rollins, B.J. Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1. Nature 2000, 404, 407–411. [Google Scholar] [CrossRef] [PubMed]
- Shi, L.L.; Song, J.; Xiong, P.; Cao, P.P.; Liao, B.; Ma, J.; Zhang, Y.N.; Zeng, M.; Liu, Y.; Wang, H.; et al. Disease-specific T-helper cell polarizing function of lesional dendritic cells in different types of chronic rhinosinusitis with nasal polyps. Am. J. Respir. Crit. Care Med. 2014, 190, 628–638. [Google Scholar] [CrossRef] [PubMed]
- Kourepini, E.; Aggelakopoulou, M.; Alissafi, T.; Paschalidis, N.; Simoes, D.C.; Panoutsakopoulou, V. Osteopontin expression by CD103- dendritic cells drives intestinal inflammation. Proc. Natl. Acad. Sci. USA 2014, 111, E856–E865. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Cao, P.P.; Shi, L.L.; Xu, K.; Yao, Y.; Liu, Z. Dendritic cells in inflammatory sinonasal diseases. Clin. Exp. Allergy 2016, 46, 894–906. [Google Scholar] [CrossRef] [PubMed]
- Wang, H.; Li, Z.Y.; Jiang, W.X.; Liao, B.; Zhai, G.T.; Wang, N.; Zhen, Z.; Ruan, J.W.; Long, X.B.; Wang, H.; et al. The activation and function of IL-36γ in neutrophilic inflammation in chronic rhinosinusitis. J. Allergy Clin. Immunol. 2018, 141, 1646–1658. [Google Scholar] [CrossRef] [Green Version]
- Annunziato, F.; Romagnani, C.; Romagnani, S. The 3 major types of innate and adaptive cell-mediated effector immunity. J. Allergy Clin. Immunol. 2015, 135, 626–635. [Google Scholar] [CrossRef]
- Wang, X.; Gao, M.; Xu, Y.; Guo, H.; Zhao, C. Expression of interleukin-22 and its significance in the pathogenesis of chronic rhinosinusitis. Int. J. Clin. Exp. Pathol. 2014, 7, 5709–5716. [Google Scholar]
- Jones, M.M.; Vanyo, S.T.; Ibraheem, W.; Maddi, A.; Visser, M.B. Treponema denticola stimulates Oncostatin M cytokine release and de novo synthesis in neutrophils and macrophages. J. Leukoc. Biol. 2020, 108, 1527–1541. [Google Scholar] [CrossRef]
- Pothoven, K.L.; Norton, J.E.; Suh, L.A.; Carter, R.G.; Harris, K.E.; Biyasheva, A.; Welch, K.; Shintani-Smith, S.; Conley, D.B.; Liu, M.C.; et al. Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease. J. Allergy Clin. Immunol. 2017, 139, 1966–1978.e1969. [Google Scholar] [CrossRef]
- Pothoven, K.L.; Norton, J.E.; Hulse, K.E.; Suh, L.A.; Carter, R.G.; Rocci, E.; Harris, K.E.; Shintani-Smith, S.; Conley, D.B.; Chandra, R.K.; et al. Oncostatin M promotes mucosal epithelial barrier dysfunction, and its expression is increased in patients with eosinophilic mucosal disease. J. Allergy Clin. Immunol. 2015, 136, 737–746.e4. [Google Scholar] [CrossRef] [Green Version]
- Van Zele, T.; Claeys, S.; Gevaert, P.; Van Maele, G.; Holtappels, G.; Van Cauwenberge, P.; Bachert, C. Differentiation of chronic sinus diseases by measurement of inflammatory mediators. Allergy 2006, 61, 1280–1289. [Google Scholar] [CrossRef]
- Derycke, L.; Eyerich, S.; Van Crombruggen, K.; Pérez-Novo, C.; Holtappels, G.; Deruyck, N.; Gevaert, P.; Bachert, C. Mixed T helper cell signatures in chronic rhinosinusitis with and without polyps. PLoS ONE 2014, 9, e97581. [Google Scholar] [CrossRef] [Green Version]
- Lin, X.S.; Luo, X.Y.; Wang, H.G.; Li, C.W.; Lin, X.; Yan, C. Expression and distribution of dendritic cells in nasal polyps. Exp. Ther. Med. 2013, 5, 1476–1480. [Google Scholar] [CrossRef] [Green Version]
- Yerkovich, S.T.; Roponen, M.; Smith, M.E.; McKenna, K.; Bosco, A.; Subrata, L.S.; Mamessier, E.; Wikström, M.E.; Le Souef, P.; Sly, P.D.; et al. Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a TH2-skewed immune response. J. Allergy Clin. Immunol. 2009, 123, 209–216.e4. [Google Scholar] [CrossRef]
- Cheong, C.; Matos, I.; Choi, J.H.; Dandamudi, D.B.; Shrestha, E.; Longhi, M.P.; Jeffrey, K.L.; Anthony, R.M.; Kluger, C.; Nchinda, G.; et al. Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas. Cell 2010, 143, 416–429. [Google Scholar] [CrossRef] [Green Version]
- Hammad, H.; Lambrecht, B.N. Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation. J. Allergy Clin. Immunol. 2006, 118, 331–336. [Google Scholar] [CrossRef]
- Novoszel, P.; Holcmann, M.; Stulnig, G.; De Sa Fernandes, C.; Zyulina, V.; Borek, I.; Linder, M.; Bogusch, A.; Drobits, B.; Bauer, T.; et al. Psoriatic skin inflammation is promoted by c-Jun/AP-1-dependent CCL2 and IL-23 expression in dendritic cells. EMBO Mol. Med. 2021, 13, e12409. [Google Scholar] [CrossRef]
- Zou, Y.; Wang, Y.; Wang, S.-B.; Kong, Y.-G.; Xu, Y.U.; Tao, Z.-Z.; Chen, S.-M. Characteristic expression and significance of CCL19 in different tissue types in chronic rhinosinusitis. Exp. Ther. Med. 2016, 11, 140–146. [Google Scholar] [CrossRef] [Green Version]
- Ellingsen, T.; Hansen, I.; Thorsen, J.; Møller, B.K.; Tarp, U.; Lottenburger, T.; Andersen, L.S.; Skjødt, H.; Pedersen, J.K.; Lauridsen, U.B.; et al. Upregulated baseline plasma CCL19 and CCR7 cell-surface expression on monocytes in early rheumatoid arthritis normalized during treatment and CCL19 correlated with radiographic progression. Scand. J. Rheumatol. 2014, 43, 91–100. [Google Scholar] [CrossRef]
- Peterson, S.; Poposki, J.A.; Nagarkar, D.R.; Chustz, R.T.; Peters, A.T.; Suh, L.A.; Carter, R.; Norton, J.; Harris, K.E.; Grammer, L.C.; et al. Increased expression of CC chemokine ligand 18 in patients with chronic rhinosinusitis with nasal polyps. J. Allergy Clin. Immunol. 2012, 129, 119–127.e9. [Google Scholar] [CrossRef] [Green Version]
- Poposki, J.A.; Uzzaman, A.; Nagarkar, D.R.; Chustz, R.T.; Peters, A.T.; Suh, L.A.; Carter, R.; Norton, J.; Harris, K.E.; Grammer, L.C.; et al. Increased expression of the chemokine CCL23 in eosinophilic chronic rhinosinusitis with nasal polyps. J. Allergy Clin. Immunol. 2011, 128, 73–81.e4. [Google Scholar] [CrossRef] [Green Version]
- Islam, S.A.; Ling, M.F.; Leung, J.; Shreffler, W.G.; Luster, A.D. Identification of human CCR8 as a CCL18 receptor. J. Exp. Med. 2013, 210, 1889–1898. [Google Scholar] [CrossRef]
- Ito, T.; Wang, Y.H.; Duramad, O.; Hori, T.; Delespesse, G.J.; Watanabe, N.; Qin, F.X.; Yao, Z.; Cao, W.; Liu, Y.J. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J. Exp. Med. 2005, 202, 1213–1223. [Google Scholar] [CrossRef] [Green Version]
- Liu, T.; Li, T.L.; Zhao, F.; Xie, C.; Liu, A.M.; Chen, X.; Song, C.; Cheng, L.; Yang, P.C. Role of thymic stromal lymphopoietin in the pathogenesis of nasal polyposis. Am. J. Med. Sci. 2011, 341, 40–47. [Google Scholar] [CrossRef]
- Liao, B.; Cao, P.P.; Zeng, M.; Zhen, Z.; Wang, H.; Zhang, Y.N.; Hu, C.Y.; Ma, J.; Li, Z.Y.; Song, J.; et al. Interaction of thymic stromal lymphopoietin, IL-33, and their receptors in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps. Allergy 2015, 70, 1169–1180. [Google Scholar] [CrossRef]
- Turner, J.H.; Li, P.; Chandra, R.K. Mucus T helper 2 biomarkers predict chronic rhinosinusitis disease severity and prior surgical intervention. Int. Forum Allergy Rhinol. 2018, 8, 1175–1183. [Google Scholar] [CrossRef]
- Karosi, T.; Csomor, P.; Hegyi, Z.; Sziklai, I. The presence of CD209 expressing dendritic cells correlates with biofilm positivity in chronic rhinosinusitis with nasal polyposis. Eur. Arch. Otorhinolaryngol. 2013, 270, 2455–2463. [Google Scholar] [CrossRef]
- Tai, J.; Han, M.; Kim, T.H. Therapeutic Strategies of Biologics in Chronic Rhinosinusitis: Current Options and Future Targets. Int. J. Mol. Sci. 2022, 23, 5523. [Google Scholar] [CrossRef]
- Mulligan, J.K.; White, D.R.; Wang, E.W.; Sansoni, S.R.; Moses, H.; Yawn, R.J.; Wagner, C.; Casey, S.E.; Mulligan, R.M.; Schlosser, R.J. Vitamin D3 deficiency increases sinus mucosa dendritic cells in pediatric chronic rhinosinusitis with nasal polyps. Otolaryngol. Head Neck Surg. 2012, 147, 773–781. [Google Scholar] [CrossRef]
- Bartels, L.E.; Hvas, C.L.; Agnholt, J.; Dahlerup, J.F.; Agger, R. Human dendritic cell antigen presentation and chemotaxis are inhibited by intrinsic 25-hydroxy vitamin D activation. Int. Immunopharmacol. 2010, 10, 922–928. [Google Scholar] [CrossRef]
- Yawn, J.; Lawrence, L.A.; Carroll, W.W.; Mulligan, J.K. Vitamin D for the treatment of respiratory diseases: Is it the end or just the beginning? J. Steroid Biochem. Mol. Biol. 2015, 148, 326–337. [Google Scholar] [CrossRef] [PubMed]
- Tak, P.P.; Balanescu, A.; Tseluyko, V.; Bojin, S.; Drescher, E.; Dairaghi, D.; Miao, S.; Marchesin, V.; Jaen, J.; Schall, T.J.; et al. Chemokine receptor CCR1 antagonist CCX354-C treatment for rheumatoid arthritis: CARAT-2, a randomised, placebo controlled clinical trial. Ann. Rheum. Dis. 2013, 72, 337–344. [Google Scholar] [CrossRef] [PubMed]
- Santella, J.B., 3rd; Gardner, D.S.; Duncia, J.V.; Wu, H.; Dhar, M.; Cavallaro, C.; Tebben, A.J.; Carter, P.H.; Barrish, J.C.; Yarde, M.; et al. Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis. J. Med. Chem. 2014, 57, 7550–7564. [Google Scholar] [CrossRef] [PubMed]
- Lee, M.C.; Saleh, R.; Achuthan, A.; Fleetwood, A.J.; Förster, I.; Hamilton, J.A.; Cook, A.D. CCL17 blockade as a therapy for osteoarthritis pain and disease. Arthritis Res. Ther. 2018, 20, 62. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Lee, K.M.; Jarnicki, A.; Achuthan, A.; Fleetwood, A.J.; Anderson, G.P.; Ellson, C.; Feeney, M.; Modis, L.K.; Smith, J.E.; Hamilton, J.A.; et al. CCL17 in Inflammation and Pain. J. Immunol. 2020, 205, 213–222. [Google Scholar] [CrossRef] [PubMed]
- Miyano, K.; Matsushita, S.; Tsuchida, T.; Nakamura, K. Inhibitory effect of a histamine 4 receptor antagonist on CCL17 and CCL22 production by monocyte-derived Langerhans cells in patients with atopic dermatitis. J. Dermatol. 2016, 43, 1024–1029. [Google Scholar] [CrossRef]
Phenotypes | Functions | |
---|---|---|
cDC1 | CD8α CD103 Clec9A XCR1 | MHC I cross-presentation. Cellular immune response. |
cDC2 | CD11b SIRPα | MHC II presentation. Humoral immune response. |
pDC | CD45RA CD317 Siglec-H | Secretion of IFN-α/β. Antiviral immune response. |
Inf-DC (MoDC) | CD14 CD16 CD64 Ly6C F4/80 | MHC I cross-presentation. MHC II presentation. Inflammatory control. |
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Tai, J.; Kwak, J.; Han, M.; Kim, T.H. Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to Phenotype. Int. J. Mol. Sci. 2022, 23, 8032. https://doi.org/10.3390/ijms23148032
Tai J, Kwak J, Han M, Kim TH. Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to Phenotype. International Journal of Molecular Sciences. 2022; 23(14):8032. https://doi.org/10.3390/ijms23148032
Chicago/Turabian StyleTai, Junhu, Jiwon Kwak, Munsoo Han, and Tae Hoon Kim. 2022. "Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to Phenotype" International Journal of Molecular Sciences 23, no. 14: 8032. https://doi.org/10.3390/ijms23148032