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Article

Major Histocompatibility Complex Class I Chain-Related α (MICA) STR Polymorphisms in COVID-19 Patients

1
Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de las Nieves, 18012 Granada, Spain
2
Programa de Doctorado en Biomedicina, University of Granada, 18016 Granada, Spain
3
Departamento Bioquímica, Biología Molecular e Inmunología III, University of Granada, 18071 Granada, Spain
4
Servicio de Análisis Clínicos, Hospital Universitario de Jaén, 23007 Jaén, Spain
5
Servicio de Medicina Interna, Hospital Universitario Virgen de las Nieves, 18012 Granada, Spain
6
Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012 Granada, Spain
7
Departamento de Medicina, University of Granada, 18071 Granada, Spain
8
Servicio de Enfermedades Infecciosas, Hospital Universitario Virgen de las Nieves, 18012 Granada, Spain
*
Authors to whom correspondence should be addressed.
These authors contributed equally to the work.
Academic Editor: Irmgard Tegeder
Int. J. Mol. Sci. 2022, 23(13), 6979; https://doi.org/10.3390/ijms23136979
Received: 7 June 2022 / Revised: 21 June 2022 / Accepted: 22 June 2022 / Published: 23 June 2022
(This article belongs to the Collection Feature Papers in Molecular Biology)
The SARS-CoV-2 disease presents different phenotypes of severity. Comorbidities, age, and being overweight are well established risk factors for severe disease. However, innate immunity plays a key role in the early control of viral infections and may condition the gravity of COVID-19. Natural Killer (NK) cells are part of innate immunity and are important in the control of virus infection by killing infected cells and participating in the development of adaptive immunity. Therefore, we studied the short tandem repeat (STR) transmembrane polymorphisms of the major histocompatibility complex class I chain-related A (MICA), an NKG2D ligand that induces activation of NK cells, among other cells. We compared the alleles and genotypes of MICA in COVID-19 patients versus healthy controls and analyzed their relation to disease severity. Our results indicate that the MICA*A9 allele is related to infection as well as to symptomatic disease but not to severe disease. The MICA*A9 allele may be a risk factor for SARS-CoV-2 infection and symptomatic disease. View Full-Text
Keywords: MICA STR polymorphisms; MICA; SARS-CoV-2; NK cells; innate immunity MICA STR polymorphisms; MICA; SARS-CoV-2; NK cells; innate immunity
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MDPI and ACS Style

Gutiérrez-Bautista, J.F.; Martinez-Chamorro, A.; Rodriguez-Nicolas, A.; Rosales-Castillo, A.; Jiménez, P.; Anderson, P.; López-Ruz, M.Á.; López-Nevot, M.Á.; Ruiz-Cabello, F. Major Histocompatibility Complex Class I Chain-Related α (MICA) STR Polymorphisms in COVID-19 Patients. Int. J. Mol. Sci. 2022, 23, 6979. https://doi.org/10.3390/ijms23136979

AMA Style

Gutiérrez-Bautista JF, Martinez-Chamorro A, Rodriguez-Nicolas A, Rosales-Castillo A, Jiménez P, Anderson P, López-Ruz MÁ, López-Nevot MÁ, Ruiz-Cabello F. Major Histocompatibility Complex Class I Chain-Related α (MICA) STR Polymorphisms in COVID-19 Patients. International Journal of Molecular Sciences. 2022; 23(13):6979. https://doi.org/10.3390/ijms23136979

Chicago/Turabian Style

Gutiérrez-Bautista, Juan F., Alba Martinez-Chamorro, Antonio Rodriguez-Nicolas, Antonio Rosales-Castillo, Pilar Jiménez, Per Anderson, Miguel Á. López-Ruz, Miguel Á. López-Nevot, and Francisco Ruiz-Cabello. 2022. "Major Histocompatibility Complex Class I Chain-Related α (MICA) STR Polymorphisms in COVID-19 Patients" International Journal of Molecular Sciences 23, no. 13: 6979. https://doi.org/10.3390/ijms23136979

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