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Review

Inflammatory Bowel Disease Treatments and Predictive Biomarkers of Therapeutic Response

1
Research Department, Sidra Medicine, Doha 26999, Qatar
2
Division of Gastroenterology, Hepatology and Nutrition, Sidra Medicine, Doha 26999, Qatar
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Jochen Mattner
Int. J. Mol. Sci. 2022, 23(13), 6966; https://doi.org/10.3390/ijms23136966
Received: 28 March 2022 / Revised: 5 June 2022 / Accepted: 6 June 2022 / Published: 23 June 2022
(This article belongs to the Special Issue Inflammatory Bowel Disease: From Pre-clinial Models into Translation)
Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammation of the gastrointestinal tract with a highly heterogeneous presentation. It has a relapsing and remitting clinical course that necessitates lifelong monitoring and treatment. Although the availability of a variety of effective therapeutic options including immunomodulators and biologics (such as TNF, CAM inhibitors) has led to a paradigm shift in the treatment outcomes and clinical management of IBD patients, some patients still either fail to respond or lose their responsiveness to therapy over time. Therefore, according to the recent Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE-II) recommendations, continuous disease monitoring from symptomatic relief to endoscopic healing along with short- and long-term therapeutic responses are critical for providing IBD patients with a tailored therapy algorithm. Moreover, considering the high unmet need for novel therapeutic approaches for IBD patients, various new modulators of cytokine signaling events (for example, JAK/TYK inhibitors), inhibitors of cytokines (for example IL-12/IL-23, IL-22, IL-36, and IL-6 inhibitors), anti-adhesion and migration strategies (for example, β7 integrin, sphingosine 1-phosphate receptors, and stem cells), as well as microbial-based therapeutics to decolonize the bed buds (for example, fecal microbiota transplantation and bacterial inhibitors) are currently being evaluated in different phases of controlled clinical trials. This review aims to offer a comprehensive overview of available treatment options and emerging therapeutic approaches for IBD patients. Furthermore, predictive biomarkers for monitoring the therapeutic response to different IBD therapies are also discussed. View Full-Text
Keywords: IBD; precision medicine; Crohn’s disease; ulcerative colitis; biomarkers; biological treatment IBD; precision medicine; Crohn’s disease; ulcerative colitis; biomarkers; biological treatment
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MDPI and ACS Style

Elhag, D.A.; Kumar, M.; Saadaoui, M.; Akobeng, A.K.; Al-Mudahka, F.; Elawad, M.; Al Khodor, S. Inflammatory Bowel Disease Treatments and Predictive Biomarkers of Therapeutic Response. Int. J. Mol. Sci. 2022, 23, 6966. https://doi.org/10.3390/ijms23136966

AMA Style

Elhag DA, Kumar M, Saadaoui M, Akobeng AK, Al-Mudahka F, Elawad M, Al Khodor S. Inflammatory Bowel Disease Treatments and Predictive Biomarkers of Therapeutic Response. International Journal of Molecular Sciences. 2022; 23(13):6966. https://doi.org/10.3390/ijms23136966

Chicago/Turabian Style

Elhag, Duaa A., Manoj Kumar, Marwa Saadaoui, Anthony K. Akobeng, Fatma Al-Mudahka, Mamoun Elawad, and Souhaila Al Khodor. 2022. "Inflammatory Bowel Disease Treatments and Predictive Biomarkers of Therapeutic Response" International Journal of Molecular Sciences 23, no. 13: 6966. https://doi.org/10.3390/ijms23136966

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