Next Article in Journal
Friction in Myocardial Anoxia Leads to Negative Excess Entropy Production, Self-Organization, and Dissipative Structures
Previous Article in Journal
Inflammatory Bowel Disease Treatments and Predictive Biomarkers of Therapeutic Response
Previous Article in Special Issue
Role of miR-133/Dio3 Axis in the T3-Dependent Modulation of Cardiac mitoK-ATP Expression
Article

miR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium

1
Department of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria
2
Unit of Human Molecular Genetics and Functional Genomics, Department of Biology, University of Padua, 35121 Padua, Italy
3
Department of Cardiothoracic Surgery, Medical University of Graz, 8036 Graz, Austria
4
Gottfried Schatz Research Center, Institute of Biophysics, Medical University of Graz, 8010 Graz, Austria
5
BioTechMed Graz, 8036 Graz, Austria
6
Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, 8010 Graz, Austria
7
Cardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA
8
Institute of Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria
9
Institute of Physiology, Faculty of Medicine, University of Maribor, 2000 Maribor, Slovenia
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Letizia Pitto and Francesca Forini
Int. J. Mol. Sci. 2022, 23(13), 6962; https://doi.org/10.3390/ijms23136962
Received: 31 May 2022 / Revised: 20 June 2022 / Accepted: 21 June 2022 / Published: 23 June 2022
(This article belongs to the Special Issue MicroRNA in Cardiac Health and Disease)
Many cardiac insults causing atrial remodeling are linked to either stretch or tachycardia, but a comparative characterization of their effects on early remodeling events in human myocardium is lacking. Here, we applied isometric stretch or sustained tachycardia at 2.5 Hz in human atrial trabeculae for 6 h followed by microarray gene expression profiling. Among largely independent expression patterns, we found a small common fraction with the microRNA miR-1183 as the highest up-regulated transcript (up to 4-fold). Both, acute stretch and tachycardia induced down-regulation of the predicted miR-1183 target genes ADAM20 and PLA2G7. Furthermore, miR-1183 was also significantly up-regulated in chronically remodeled atrial samples from patients with persistent atrial fibrillation (3-fold up-regulation versus sinus rhythm samples), and in ventricular myocardium from dilative cardiomyopathy hearts (2-fold up-regulation) as compared to non-failing controls. In sum, although stretch and tachycardia show distinct transcriptomic signatures in human atrial myocardium, both cardiac insults consistently regulate the expression of miR-1183 and its downstream targets in acute and chronic remodeling. Thus, elevated expression of miR-1183 might serve as a tissue biomarker for atrial remodeling and might be of potential functional significance in cardiac disease. View Full-Text
Keywords: stretch; tachycardia; cardiac remodeling; microRNA; MIR1183; miR-1183; human myocardium; biomarker stretch; tachycardia; cardiac remodeling; microRNA; MIR1183; miR-1183; human myocardium; biomarker
Show Figures

Figure 1

MDPI and ACS Style

Djalinac, N.; Kolesnik, E.; Maechler, H.; Scheruebel-Posch, S.; Pelzmann, B.; Rainer, P.P.; Foessl, I.; Wallner, M.; Scherr, D.; Heinemann, A.; Sedej, S.; Ljubojevic-Holzer, S.; von Lewinski, D.; Bisping, E. miR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium. Int. J. Mol. Sci. 2022, 23, 6962. https://doi.org/10.3390/ijms23136962

AMA Style

Djalinac N, Kolesnik E, Maechler H, Scheruebel-Posch S, Pelzmann B, Rainer PP, Foessl I, Wallner M, Scherr D, Heinemann A, Sedej S, Ljubojevic-Holzer S, von Lewinski D, Bisping E. miR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium. International Journal of Molecular Sciences. 2022; 23(13):6962. https://doi.org/10.3390/ijms23136962

Chicago/Turabian Style

Djalinac, Natasa, Ewald Kolesnik, Heinrich Maechler, Susanne Scheruebel-Posch, Brigitte Pelzmann, Peter P. Rainer, Ines Foessl, Markus Wallner, Daniel Scherr, Akos Heinemann, Simon Sedej, Senka Ljubojevic-Holzer, Dirk von Lewinski, and Egbert Bisping. 2022. "miR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium" International Journal of Molecular Sciences 23, no. 13: 6962. https://doi.org/10.3390/ijms23136962

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop