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Antiviral Characterization of Advanced Materials: Use of Bacteriophage Phi 6 as Surrogate of Enveloped Viruses Such as SARS-CoV-2

Biomaterials and Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, c/Guillem de Castro 94, 46001 Valencia, Spain
Academic Editors: Iolanda Francolini and Marcel Popa
Int. J. Mol. Sci. 2022, 23(10), 5335; https://doi.org/10.3390/ijms23105335
Received: 26 March 2022 / Revised: 30 April 2022 / Accepted: 9 May 2022 / Published: 10 May 2022
(This article belongs to the Collection State-of-the-Art Macromolecules in Spain)
The bacteriophage phi 6 is a virus that belongs to a different Baltimore group than SARS-CoV-2 (group III instead of IV). However, it has a round-like shape and a lipid envelope like SARS-CoV-2, which render it very useful to be used as a surrogate of this infectious pathogen for biosafety reasons. Thus, recent antiviral studies have demonstrated that antiviral materials such as calcium alginate hydrogels, polyester-based fabrics coated with benzalkonium chloride (BAK), polyethylene terephthalate (PET) coated with BAK and polyester-based fabrics coated with cranberry extracts or solidified hand soap produce similar log reductions in viral titers of both types of enveloped viruses after similar viral contact times. Therefore, researchers with no access to biosafety level 3 facilities can perform antiviral tests of a broad range of biomaterials, composites, nanomaterials, nanocomposites, coatings and compounds against the bacteriophage phi 6 as a biosafe viral model of SARS-CoV-2. In fact, this bacteriophage has been used as a surrogate of SARS-CoV-2 to test a broad range of antiviral materials and compounds of different chemical natures (polymers, metals, alloys, ceramics, composites, etc.) and forms (films, coatings, nanomaterials, extracts, porous supports produced by additive manufacturing, etc.) during the current pandemic. Furthermore, this biosafe viral model has also been used as a surrogate of SARS-CoV-2 and other highly pathogenic enveloped viruses such as Ebola and influenza in a wide range of biotechnological applications. View Full-Text
Keywords: bacteriophage phi 6; SARS-CoV-2; biosafety conditions; antiviral materials; antiviral characterization; coatings; nanomaterials; composites; films; extracts; porous supports bacteriophage phi 6; SARS-CoV-2; biosafety conditions; antiviral materials; antiviral characterization; coatings; nanomaterials; composites; films; extracts; porous supports
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MDPI and ACS Style

Serrano-Aroca, Á. Antiviral Characterization of Advanced Materials: Use of Bacteriophage Phi 6 as Surrogate of Enveloped Viruses Such as SARS-CoV-2. Int. J. Mol. Sci. 2022, 23, 5335. https://doi.org/10.3390/ijms23105335

AMA Style

Serrano-Aroca Á. Antiviral Characterization of Advanced Materials: Use of Bacteriophage Phi 6 as Surrogate of Enveloped Viruses Such as SARS-CoV-2. International Journal of Molecular Sciences. 2022; 23(10):5335. https://doi.org/10.3390/ijms23105335

Chicago/Turabian Style

Serrano-Aroca, Ángel. 2022. "Antiviral Characterization of Advanced Materials: Use of Bacteriophage Phi 6 as Surrogate of Enveloped Viruses Such as SARS-CoV-2" International Journal of Molecular Sciences 23, no. 10: 5335. https://doi.org/10.3390/ijms23105335

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