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Review

Role of Selenium in Viral Infections with a Major Focus on SARS-CoV-2

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Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA
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College of Arts, Sciences & Education, Florida International University, Miami, FL 33199, USA
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Author to whom correspondence should be addressed.
Academic Editors: Petra A. Tsuji and Dolph L. Hatfield
Int. J. Mol. Sci. 2022, 23(1), 280; https://doi.org/10.3390/ijms23010280
Received: 9 December 2021 / Revised: 22 December 2021 / Accepted: 24 December 2021 / Published: 28 December 2021
(This article belongs to the Special Issue Molecular Biology of Selenium in Health and Disease)
Viral infections have afflicted human health and despite great advancements in scientific knowledge and technologies, continue to affect our society today. The current coronavirus (COVID-19) pandemic has put a spotlight on the need to review the evidence on the impact of nutritional strategies to maintain a healthy immune system, particularly in instances where there are limited therapeutic treatments. Selenium, an essential trace element in humans, has a long history of lowering the occurrence and severity of viral infections. Much of the benefits derived from selenium are due to its incorporation into selenocysteine, an important component of proteins known as selenoproteins. Viral infections are associated with an increase in reactive oxygen species and may result in oxidative stress. Studies suggest that selenium deficiency alters immune response and viral infection by increasing oxidative stress and the rate of mutations in the viral genome, leading to an increase in pathogenicity and damage to the host. This review examines viral infections, including the novel SARS-CoV-2, in the context of selenium, in order to inform potential nutritional strategies to maintain a healthy immune system. View Full-Text
Keywords: selenium; selenoproteins; virus; viral; infection; reactive oxygen species; antioxidant; HIV; HCV; HBV; coxsackie virus; influenza; glutathione peroxidase; thioredoxin reductase selenium; selenoproteins; virus; viral; infection; reactive oxygen species; antioxidant; HIV; HCV; HBV; coxsackie virus; influenza; glutathione peroxidase; thioredoxin reductase
MDPI and ACS Style

Martinez, S.S.; Huang, Y.; Acuna, L.; Laverde, E.; Trujillo, D.; Barbieri, M.A.; Tamargo, J.; Campa, A.; Baum, M.K. Role of Selenium in Viral Infections with a Major Focus on SARS-CoV-2. Int. J. Mol. Sci. 2022, 23, 280. https://doi.org/10.3390/ijms23010280

AMA Style

Martinez SS, Huang Y, Acuna L, Laverde E, Trujillo D, Barbieri MA, Tamargo J, Campa A, Baum MK. Role of Selenium in Viral Infections with a Major Focus on SARS-CoV-2. International Journal of Molecular Sciences. 2022; 23(1):280. https://doi.org/10.3390/ijms23010280

Chicago/Turabian Style

Martinez, Sabrina S., Yongjun Huang, Leonardo Acuna, Eduardo Laverde, David Trujillo, Manuel A. Barbieri, Javier Tamargo, Adriana Campa, and Marianna K. Baum. 2022. "Role of Selenium in Viral Infections with a Major Focus on SARS-CoV-2" International Journal of Molecular Sciences 23, no. 1: 280. https://doi.org/10.3390/ijms23010280

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