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Review

Anaphylaxis: Focus on Transcription Factor Activity

1
Biochemistry Unit, Biomedicine Department, Faculty of Medicine, University of Barcelona, 08036 Barcelona, Spain
2
Clinical and Experimental Respiratory Immunoallergy (IRCE), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
3
Allergy Section, Pneumology Department, Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain
4
ARADyAL (Asthma, Drug Adverse Reactions and Allergy) Research Network, 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Maren von Köckritz-Blickwede
Int. J. Mol. Sci. 2021, 22(9), 4935; https://doi.org/10.3390/ijms22094935
Received: 29 March 2021 / Revised: 22 April 2021 / Accepted: 2 May 2021 / Published: 6 May 2021
(This article belongs to the Special Issue Mast Cells: From Host Defense to Pathology)
Anaphylaxis is a severe allergic reaction, rapid in onset, and can lead to fatal consequences if not promptly treated. The incidence of anaphylaxis has risen at an alarming rate in past decades and continues to rise. Therefore, there is a general interest in understanding the molecular mechanism that leads to an exacerbated response. The main effector cells are mast cells, commonly triggered by stimuli that involve the IgE-dependent or IgE-independent pathway. These signaling pathways converge in the release of proinflammatory mediators, such as histamine, tryptases, prostaglandins, etc., in minutes. The action and cell targets of these proinflammatory mediators are linked to the pathophysiologic consequences observed in this severe allergic reaction. While many molecules are involved in cellular regulation, the expression and regulation of transcription factors involved in the synthesis of proinflammatory mediators and secretory granule homeostasis are of special interest, due to their ability to control gene expression and change phenotype, and they may be key in the severity of the entire reaction. In this review, we will describe our current understanding of the pathophysiology of human anaphylaxis, focusing on the transcription factors’ contributions to this systemic hypersensitivity reaction. Host mutation in transcription factor expression, or deregulation of their activity in an anaphylaxis context, will be updated. So far, the risk of anaphylaxis is unpredictable thus, increasing our knowledge of the molecular mechanism that leads and regulates mast cell activity will enable us to improve our understanding of how anaphylaxis can be prevented or treated. View Full-Text
Keywords: Mast cells; transcription factors; anaphylaxis; proinflammatory mediators Mast cells; transcription factors; anaphylaxis; proinflammatory mediators
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MDPI and ACS Style

Guo, Y.; Proaño-Pérez, E.; Muñoz-Cano, R.; Martin, M. Anaphylaxis: Focus on Transcription Factor Activity. Int. J. Mol. Sci. 2021, 22, 4935. https://doi.org/10.3390/ijms22094935

AMA Style

Guo Y, Proaño-Pérez E, Muñoz-Cano R, Martin M. Anaphylaxis: Focus on Transcription Factor Activity. International Journal of Molecular Sciences. 2021; 22(9):4935. https://doi.org/10.3390/ijms22094935

Chicago/Turabian Style

Guo, Yanru, Elizabeth Proaño-Pérez, Rosa Muñoz-Cano, and Margarita Martin. 2021. "Anaphylaxis: Focus on Transcription Factor Activity" International Journal of Molecular Sciences 22, no. 9: 4935. https://doi.org/10.3390/ijms22094935

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