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Adenosine Signaling in Mast Cells and Allergic Diseases

Clinical and Experimental Respiratory Immunoallergy (IRCE), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
Biochemistry and Molecular Biology Unit, Biomedicine Department, Faculty of Medicine, University of Barcelona, 08036 Barcelona, Spain
ARADyAL, Instituto de Salud Carlos III, 28220 Madrid, Spain
Allergy Section, Hospital Clinic, Universitat de Barcelona, 08036 Barcelona, Spain
Author to whom correspondence should be addressed.
Both authors must be considered last authors.
Academic Editor: Maurizio Battino
Int. J. Mol. Sci. 2021, 22(10), 5203;
Received: 31 March 2021 / Revised: 10 May 2021 / Accepted: 12 May 2021 / Published: 14 May 2021
(This article belongs to the Special Issue Mast Cells: From Host Defense to Pathology)
Adenosine is a nucleoside involved in the pathogenesis of allergic diseases. Its effects are mediated through its binding to G protein-coupled receptors: A1, A2a, A2b and A3. The receptors differ in the type of G protein they recruit, in the effect on adenylyl cyclase (AC) activity and the downstream signaling pathway triggered. Adenosine can produce both an enhancement and an inhibition of mast cell degranulation, indicating that adenosine effects on these receptors is controversial and remains to be clarified. Depending on the study model, A1, A2b, and A3 receptors have shown anti- or pro-inflammatory activity. However, most studies reported an anti-inflammatory activity of A2a receptor. The precise knowledge of the adenosine mechanism of action may allow to develop more efficient therapies for allergic diseases by using selective agonist and antagonist against specific receptor subtypes. View Full-Text
Keywords: adenosine; adenosine receptors; G protein; mast cells; allergic diseases; asthma adenosine; adenosine receptors; G protein; mast cells; allergic diseases; asthma
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MDPI and ACS Style

Garcia-Garcia, L.; Olle, L.; Martin, M.; Roca-Ferrer, J.; Muñoz-Cano, R. Adenosine Signaling in Mast Cells and Allergic Diseases. Int. J. Mol. Sci. 2021, 22, 5203.

AMA Style

Garcia-Garcia L, Olle L, Martin M, Roca-Ferrer J, Muñoz-Cano R. Adenosine Signaling in Mast Cells and Allergic Diseases. International Journal of Molecular Sciences. 2021; 22(10):5203.

Chicago/Turabian Style

Garcia-Garcia, Lucia, Laia Olle, Margarita Martin, Jordi Roca-Ferrer, and Rosa Muñoz-Cano. 2021. "Adenosine Signaling in Mast Cells and Allergic Diseases" International Journal of Molecular Sciences 22, no. 10: 5203.

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