Next Article in Journal
Hypergravity Load Modulates Acetaminophen Nephrotoxicity via Endoplasmic Reticulum Stress in Association with Hepatic microRNA-122 Expression
Next Article in Special Issue
Precious-Metal-Decorated Chromium(IV) Oxide Nanowires as Efficient Catalysts for 2,4-Toluenediamine Synthesis
Previous Article in Journal
MSCs Become Collagen-Type I Producing Cells with Different Phenotype in Allogeneic and Syngeneic Bone Marrow Transplantation
Previous Article in Special Issue
Melanin-Like Nanomedicine in Photothermal Therapy Applications
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 22
Issue 9
10.3390/ijms22094898
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Magnetic Particles with Polymeric Shells Bearing Cholesterol Moieties Sensitize Breast Cancer Cells to Low Doses of Doxorubicin

by
Karolina H. Markiewicz
1,*,
Katarzyna Niemirowicz-Laskowska
2,*,
Dawid Szymczuk
1,3,
Kacper Makarewicz
1,
Iwona Misztalewska-Turkowicz
1,
Przemysław Wielgat
4,
Anna M. Majcher-Fitas
5,
Sylwia Milewska
2,
Halina Car
2 and
Agnieszka Z. Wilczewska
1,*
1
Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1k, 15-245 Bialystok, Poland
2
Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, 15-361 Bialystok, Poland
3
Doctoral School of Exact and Natural Sciences, University of Bialystok, 15-245 Bialystok, Poland
4
Department of Clinical Pharmacology, Medical University of Bialystok, Waszyngtona 15A, 15-274 Bialystok, Poland
5
Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Krakow, Poland
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(9), 4898; https://doi.org/10.3390/ijms22094898
Submission received: 8 March 2021 / Revised: 27 April 2021 / Accepted: 2 May 2021 / Published: 5 May 2021
(This article belongs to the Special Issue Nanoparticles: From Synthesis to Applications)
Browse Figures
Versions Notes

Abstract

One of the promising strategies for improvement of cancer treatment is application of a combination therapy. The aim of this study was to investigate the anticancer activity of nanoformulations containing doxorubicin and iron oxide particles covered with polymeric shells bearing cholesterol moieties. It was postulated that due to high affinity to cell membranes, particles comprising poly(cholesteryl acrylate) can sensitize cancer cells to doxorubicin chemotherapy. The performed analyses revealed that the developed systems are effective against the human breast cancer cell lines MCF-7 and MDA-MB-231 even at low doses of the active compound applied (0.5 µM). Additionally, high compatibility and lack of toxicity of the tested materials against human red blood cells, immune (monocytic THP-1) cells, and cardiomyocyte H9C2(2-1) cells was demonstrated. Synergistic effects observed upon administration of doxorubicin with polymer–iron oxide hybrids comprising poly(cholesteryl acrylate) may provide an opportunity to limit toxicity of the drug and to improve its therapeutic efficiency at the same time.
Keywords: polymer–iron oxide particles; doxorubicin; anticancer activity; combination therapy polymer–iron oxide particles; doxorubicin; anticancer activity; combination therapy

Share and Cite

MDPI and ACS Style

Markiewicz, K.H.; Niemirowicz-Laskowska, K.; Szymczuk, D.; Makarewicz, K.; Misztalewska-Turkowicz, I.; Wielgat, P.; Majcher-Fitas, A.M.; Milewska, S.; Car, H.; Wilczewska, A.Z. Magnetic Particles with Polymeric Shells Bearing Cholesterol Moieties Sensitize Breast Cancer Cells to Low Doses of Doxorubicin. Int. J. Mol. Sci. 2021, 22, 4898. https://doi.org/10.3390/ijms22094898

AMA Style

Markiewicz KH, Niemirowicz-Laskowska K, Szymczuk D, Makarewicz K, Misztalewska-Turkowicz I, Wielgat P, Majcher-Fitas AM, Milewska S, Car H, Wilczewska AZ. Magnetic Particles with Polymeric Shells Bearing Cholesterol Moieties Sensitize Breast Cancer Cells to Low Doses of Doxorubicin. International Journal of Molecular Sciences. 2021; 22(9):4898. https://doi.org/10.3390/ijms22094898

Chicago/Turabian Style

Markiewicz, Karolina H., Katarzyna Niemirowicz-Laskowska, Dawid Szymczuk, Kacper Makarewicz, Iwona Misztalewska-Turkowicz, Przemysław Wielgat, Anna M. Majcher-Fitas, Sylwia Milewska, Halina Car, and Agnieszka Z. Wilczewska. 2021. "Magnetic Particles with Polymeric Shells Bearing Cholesterol Moieties Sensitize Breast Cancer Cells to Low Doses of Doxorubicin" International Journal of Molecular Sciences 22, no. 9: 4898. https://doi.org/10.3390/ijms22094898

APA Style

Markiewicz, K. H., Niemirowicz-Laskowska, K., Szymczuk, D., Makarewicz, K., Misztalewska-Turkowicz, I., Wielgat, P., Majcher-Fitas, A. M., Milewska, S., Car, H., & Wilczewska, A. Z. (2021). Magnetic Particles with Polymeric Shells Bearing Cholesterol Moieties Sensitize Breast Cancer Cells to Low Doses of Doxorubicin. International Journal of Molecular Sciences, 22(9), 4898. https://doi.org/10.3390/ijms22094898

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop