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Review

Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers

1
Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research of PAS, Tuwima 10, 10-748 Olsztyn, Poland
2
Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK
3
Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Víctor Sánchez-Margalet
Int. J. Mol. Sci. 2021, 22(8), 4270; https://doi.org/10.3390/ijms22084270
Received: 25 March 2021 / Revised: 13 April 2021 / Accepted: 16 April 2021 / Published: 20 April 2021
(This article belongs to the Special Issue Leptin)
The complex nature of folliculogenesis regulation accounts for its susceptibility to maternal physiological fitness. In obese mothers, progressive expansion of adipose tissue culminates with severe hyperestrogenism and hyperleptinemia with detrimental effects for ovarian performance. Indeed, maternal obesity is associated with the establishment of ovarian leptin resistance. This review summarizes current knowledge on potential effects of impaired leptin signaling throughout folliculogenesis and oocyte developmental competence in mice and women. View Full-Text
Keywords: leptin; obesity; ovary; folliculogenesis; oocyte leptin; obesity; ovary; folliculogenesis; oocyte
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MDPI and ACS Style

Wołodko, K.; Castillo-Fernandez, J.; Kelsey, G.; Galvão, A. Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers. Int. J. Mol. Sci. 2021, 22, 4270. https://doi.org/10.3390/ijms22084270

AMA Style

Wołodko K, Castillo-Fernandez J, Kelsey G, Galvão A. Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers. International Journal of Molecular Sciences. 2021; 22(8):4270. https://doi.org/10.3390/ijms22084270

Chicago/Turabian Style

Wołodko, Karolina; Castillo-Fernandez, Juan; Kelsey, Gavin; Galvão, António. 2021. "Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers" Int. J. Mol. Sci. 22, no. 8: 4270. https://doi.org/10.3390/ijms22084270

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