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Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome

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Department of Clinical Diagnostics, Vitebsk State Academy of Veterinary Medicine [UO VGAVM], 7/11 Dovatora str., 210026 Vitebsk, Belarus
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Center of Collective Usage, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilova Street, 119334 Moscow, Russia
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Laboratory of Medical Genetics, Institute of Experimental Cardiology, National Medical Research Center of Cardiology, 121552 Moscow, Russia
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Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Institute of Human Morphology, 3 Tsyurupa Street, 117418 Moscow, Russia
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Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha 2713, Qatar
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Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha 2713, Qatar
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Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon
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Federal State Autonomous Educational Institution of Higher Education, I. M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubenskaya Street, 119991 Moscow, Russia
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Federal Research Centre for Nutrition, Biotechnology and Food Safety, 2/14 Ustinsky Passage, 109240 Moscow, Russia
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Pirogov Russian National Research Medical University, 1 Ostrovitianov Street, 117997 Moscow, Russia
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V.A. Nasonova Institute of Rheumatology, 34A Kashirskoye Shosse, 115522 Moscow, Russia
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Laboratory of Angiopathology, The Institute of General Pathology and Pathophysiology, 8 Baltiyskaya Street, 125315 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editors: Maria S. Fernandez-Alfonso and Marta Gil-Ortega
Int. J. Mol. Sci. 2021, 22(8), 3923; https://doi.org/10.3390/ijms22083923
Received: 26 February 2021 / Revised: 26 March 2021 / Accepted: 31 March 2021 / Published: 10 April 2021
(This article belongs to the Special Issue Recent Advances in Molecular Research of Metabolic Disorders)
Polycystic ovarian syndrome (PCOS) is the most common endocrine–metabolic disorder affecting a vast population worldwide; it is linked with anovulation, mitochondrial dysfunctions and hormonal disbalance. Mutations in mtDNA have been identified in PCOS patients and likely play an important role in PCOS aetiology and pathogenesis; however, their causative role in PCOS development requires further investigation. As a low-grade chronic inflammation disease, PCOS patients have permanently elevated levels of inflammatory markers (TNF-α, CRP, IL-6, IL-8, IL-18). In this review, we summarise recent data regarding the role of mtDNA mutations and mitochondrial malfunctions in PCOS pathogenesis. Furthermore, we discuss recent papers dedicated to the identification of novel biomarkers for early PCOS diagnosis. Finally, traditional and new mitochondria-targeted treatments are discussed. This review intends to emphasise the key role of oxidative stress and chronic inflammation in PCOS pathogenesis; however, the exact molecular mechanism is mostly unknown and requires further investigation. View Full-Text
Keywords: polycystic ovarian syndrome; insulin resistance; chronic inflammation; oxidative stress; mitochondrial mutations polycystic ovarian syndrome; insulin resistance; chronic inflammation; oxidative stress; mitochondrial mutations
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MDPI and ACS Style

Dabravolski, S.A.; Nikiforov, N.G.; Eid, A.H.; Nedosugova, L.V.; Starodubova, A.V.; Popkova, T.V.; Bezsonov, E.E.; Orekhov, A.N. Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome. Int. J. Mol. Sci. 2021, 22, 3923. https://doi.org/10.3390/ijms22083923

AMA Style

Dabravolski SA, Nikiforov NG, Eid AH, Nedosugova LV, Starodubova AV, Popkova TV, Bezsonov EE, Orekhov AN. Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome. International Journal of Molecular Sciences. 2021; 22(8):3923. https://doi.org/10.3390/ijms22083923

Chicago/Turabian Style

Dabravolski, Siarhei A.; Nikiforov, Nikita G.; Eid, Ali H.; Nedosugova, Ludmila V.; Starodubova, Antonina V.; Popkova, Tatyana V.; Bezsonov, Evgeny E.; Orekhov, Alexander N. 2021. "Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome" Int. J. Mol. Sci. 22, no. 8: 3923. https://doi.org/10.3390/ijms22083923

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