Reconstruction of Critical Nerve Defects Using Allogenic Nerve Tissue: A Review of Current Approaches

Kornfeld, Tim; Borger, Anton; Radtke, Christine

doi:10.3390/ijms22073515

Open AccessReview

Reconstruction of Critical Nerve Defects Using Allogenic Nerve Tissue: A Review of Current Approaches

by

Tim Kornfeld

,

Anton Borger

and

Christine Radtke

^*

Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2021, 22(7), 3515; https://doi.org/10.3390/ijms22073515

Submission received: 14 February 2021 / Revised: 23 March 2021 / Accepted: 25 March 2021 / Published: 29 March 2021

(This article belongs to the Special Issue Regenerative Medicine for Peripheral Nerve Injury: Recent Advances, Emerging Therapies and Future Directions)

Download

Browse Figure

Versions Notes

Abstract

Regardless of the nerve defect length, nerve injury is a debilitating condition for the affected patient that results in loss of sensory and motor function. These functional impairments can have a profound impact on the patient’s quality of life. Surgical approaches for the treatment of short segment nerve defects are well-established. Autologous nerve transplantation, considered the gold standard, and the use of artificial nerve grafts are safe and successful procedures for short segment nerve defect reconstruction. Long segment nerve defects which extend 3.0 cm or more are more problematic for repair. Methods for reconstruction of long defects are limited. Artificial nerve grafts often fail to regenerate and autologous nerve grafts are limited in length and number. Cadaveric processed/unprocessed nerve allografts are a promising alternative in nerve surgery. This review gives a systematic overview on pre-clinical and clinical approaches in nerve allograft transplantation.

Keywords: FDA; artificial nerve grafts; allograft

Share and Cite

MDPI and ACS Style

Kornfeld, T.; Borger, A.; Radtke, C. Reconstruction of Critical Nerve Defects Using Allogenic Nerve Tissue: A Review of Current Approaches. Int. J. Mol. Sci. 2021, 22, 3515. https://doi.org/10.3390/ijms22073515

AMA Style

Kornfeld T, Borger A, Radtke C. Reconstruction of Critical Nerve Defects Using Allogenic Nerve Tissue: A Review of Current Approaches. International Journal of Molecular Sciences. 2021; 22(7):3515. https://doi.org/10.3390/ijms22073515

Chicago/Turabian Style

Kornfeld, Tim, Anton Borger, and Christine Radtke. 2021. "Reconstruction of Critical Nerve Defects Using Allogenic Nerve Tissue: A Review of Current Approaches" International Journal of Molecular Sciences 22, no. 7: 3515. https://doi.org/10.3390/ijms22073515

APA Style

Kornfeld, T., Borger, A., & Radtke, C. (2021). Reconstruction of Critical Nerve Defects Using Allogenic Nerve Tissue: A Review of Current Approaches. International Journal of Molecular Sciences, 22(7), 3515. https://doi.org/10.3390/ijms22073515

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Reconstruction of Critical Nerve Defects Using Allogenic Nerve Tissue: A Review of Current Approaches

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI