Next Article in Journal
The ‘Jekyll and Hyde’ of Gluconeogenesis: Early Life Adversity, Later Life Stress, and Metabolic Disturbances
Next Article in Special Issue
Connection between Periodontitis-Induced Low-Grade Endotoxemia and Systemic Diseases: Neutrophils as Protagonists and Targets
Previous Article in Journal
Mitochondrial and Autophagic Regulation of Adult Neurogenesis in the Healthy and Diseased Brain
Previous Article in Special Issue
Expression of the SARS-CoV-2 Receptor ACE2 and Proinflammatory Cytokines Induced by the Periodontopathic Bacterium Fusobacterium nucleatum in Human Respiratory Epithelial Cells
Article

Lantibiotics Produced by Oral Inhabitants as a Trigger for Dysbiosis of Human Intestinal Microbiota

1
Department of Infectious Diseases, Kyorin University School of Medicine, Tokyo 181-8611, Japan
2
Division of Oral Restitution, Department of Pediatric Dentistry, Graduate School, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
3
Institute of Laboratory Animals, Graduate School of Medicine, Kyorin University School of Medicine, Tokyo 181-8611, Japan
4
Central Research Institute, Miyarisan Pharmaceutical Co. Ltd., Tokyo 114-0016, Japan
5
Core Laboratory for Proteomics and Genomics, Kyorin University School of Medicine, Tokyo 181-8611, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Kenichi Imai
Int. J. Mol. Sci. 2021, 22(7), 3343; https://doi.org/10.3390/ijms22073343
Received: 26 February 2021 / Revised: 16 March 2021 / Accepted: 22 March 2021 / Published: 25 March 2021
(This article belongs to the Special Issue Molecular Links between Periodontitis and Systemic Diseases)
Lantibiotics are a type of bacteriocin produced by Gram-positive bacteria and have a wide spectrum of Gram-positive antimicrobial activity. In this study, we determined that Mutacin I/III and Smb (a dipeptide lantibiotic), which are mainly produced by the widespread cariogenic bacterium Streptococcus mutans, have strong antimicrobial activities against many of the Gram-positive bacteria which constitute the intestinal microbiota. These lantibiotics also demonstrate resistance to acid and temperature. Based on these features, we predicted that lantibiotics may be able to persist into the intestinal tract maintaining a strong antimicrobial activity, affecting the intestinal microbiota. Saliva and fecal samples from 69 subjects were collected to test this hypothesis and the presence of lantibiotics and the composition of the intestinal microbiota were examined. We demonstrate that subjects possessing lantibiotic-producing bacteria in their oral cavity exhibited a tendency of decreased species richness and have significantly reduced abundance of the phylum Firmicutes in their intestinal microbiota. Similar results were obtained in the fecal microbiota of mice fed with S. mutans culture supernatant containing the lantibiotic bacteriocin Mutacin I. These results showed that lantibiotic bacteriocins produced in the oral cavity perturb the intestinal microbiota and suggest that oral bacteria may be one of the causative factors of intestinal microbiota dysbiosis. View Full-Text
Keywords: lantibiotics; Mutacin; Smb; oral bacteria; intestinal microbiota; dysbiosis lantibiotics; Mutacin; Smb; oral bacteria; intestinal microbiota; dysbiosis
Show Figures

Figure 1

MDPI and ACS Style

Yonezawa, H.; Motegi, M.; Oishi, A.; Hojo, F.; Higashi, S.; Nozaki, E.; Oka, K.; Takahashi, M.; Osaki, T.; Kamiya, S. Lantibiotics Produced by Oral Inhabitants as a Trigger for Dysbiosis of Human Intestinal Microbiota. Int. J. Mol. Sci. 2021, 22, 3343. https://doi.org/10.3390/ijms22073343

AMA Style

Yonezawa H, Motegi M, Oishi A, Hojo F, Higashi S, Nozaki E, Oka K, Takahashi M, Osaki T, Kamiya S. Lantibiotics Produced by Oral Inhabitants as a Trigger for Dysbiosis of Human Intestinal Microbiota. International Journal of Molecular Sciences. 2021; 22(7):3343. https://doi.org/10.3390/ijms22073343

Chicago/Turabian Style

Yonezawa, Hideo; Motegi, Mizuho; Oishi, Atsushi; Hojo, Fuhito; Higashi, Seiya; Nozaki, Eriko; Oka, Kentaro; Takahashi, Motomichi; Osaki, Takako; Kamiya, Shigeru. 2021. "Lantibiotics Produced by Oral Inhabitants as a Trigger for Dysbiosis of Human Intestinal Microbiota" Int. J. Mol. Sci. 22, no. 7: 3343. https://doi.org/10.3390/ijms22073343

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop