Potential of Superhydrophobic Surface for Blood-Contacting Medical Devices
1
School of Postgraduate Studies, International Medical University, Kuala Lumpur 57000, Malaysia
2
Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
3
Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(7), 3341; https://doi.org/10.3390/ijms22073341
Received: 3 February 2021
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Revised: 21 February 2021
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Accepted: 22 February 2021
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Published: 24 March 2021
(This article belongs to the Section Materials Science)
Medical devices are indispensable in the healthcare setting, ranging from diagnostic tools to therapeutic instruments, and even supporting equipment. However, these medical devices may be associated with life-threatening complications when exposed to blood. To date, medical device-related infections have been a major drawback causing high mortality. Device-induced hemolysis, albeit often neglected, results in negative impacts, including thrombotic events. Various strategies have been approached to overcome these issues, but the outcomes are yet to be considered as successful. Recently, superhydrophobic materials or coatings have been brought to attention in various fields. Superhydrophobic surfaces are proposed to be ideal blood-compatible biomaterials attributed to their beneficial characteristics. Reports have substantiated the blood repellence of a superhydrophobic surface, which helps to prevent damage on blood cells upon cell–surface interaction, thereby alleviating subsequent complications. The anti-biofouling effect of superhydrophobic surfaces is also desired in medical devices as it resists the adhesion of organic substances, such as blood cells and microorganisms. In this review, we will focus on the discussion about the potential contribution of superhydrophobic surfaces on enhancing the hemocompatibility of blood-contacting medical devices.
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Keywords:
superhydrophobic; medical device; antihemolytic; antithrombotic; antibacterial; anti-biofouling; blood compatible
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MDPI and ACS Style
Wu, X.H.; Liew, Y.K.; Mai, C.-W.; Then, Y.Y. Potential of Superhydrophobic Surface for Blood-Contacting Medical Devices. Int. J. Mol. Sci. 2021, 22, 3341. https://doi.org/10.3390/ijms22073341
AMA Style
Wu XH, Liew YK, Mai C-W, Then YY. Potential of Superhydrophobic Surface for Blood-Contacting Medical Devices. International Journal of Molecular Sciences. 2021; 22(7):3341. https://doi.org/10.3390/ijms22073341
Chicago/Turabian StyleWu, Xun H., Yun K. Liew, Chun-Wai Mai, and Yoon Y. Then. 2021. "Potential of Superhydrophobic Surface for Blood-Contacting Medical Devices" International Journal of Molecular Sciences 22, no. 7: 3341. https://doi.org/10.3390/ijms22073341
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