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Article

Investigating Primary Cilia during Peripheral Nervous System Formation

Department of Molecular Life Sciences and Neuroscience Center Zurich, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
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Author to whom correspondence should be addressed.
Academic Editors: Lies De Groef and Lieve Moons
Int. J. Mol. Sci. 2021, 22(6), 3176; https://doi.org/10.3390/ijms22063176
Received: 31 January 2021 / Revised: 16 March 2021 / Accepted: 16 March 2021 / Published: 20 March 2021
(This article belongs to the Special Issue Molecular Mechanisms of Neural Circuit Development and Regeneration)
The primary cilium plays a pivotal role during the embryonic development of vertebrates. It acts as a somatic signaling hub for specific pathways, such as Sonic Hedgehog signaling. In humans, mutations in genes that cause dysregulation of ciliogenesis or ciliary function lead to severe developmental disorders called ciliopathies. Beyond its role in early morphogenesis, growing evidence points towards an essential function of the primary cilium in neural circuit formation in the central nervous system. However, very little is known about a potential role in the formation of the peripheral nervous system. Here, we investigate the presence of the primary cilium in neural crest cells and their derivatives in the trunk of developing chicken embryos in vivo. We found that neural crest cells, sensory neurons, and boundary cap cells all bear a primary cilium during key stages of early peripheral nervous system formation. Moreover, we describe differences in the ciliation of neuronal cultures of different populations from the peripheral and central nervous systems. Our results offer a framework for further in vivo and in vitro investigations on specific roles that the primary cilium might play during peripheral nervous system formation. View Full-Text
Keywords: primary cilium; ciliogenesis; neural circuit formation; neural crest cells; DRG; boundary cap cells; sympathetic ganglia; PNS primary cilium; ciliogenesis; neural circuit formation; neural crest cells; DRG; boundary cap cells; sympathetic ganglia; PNS
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MDPI and ACS Style

Yusifov, E.; Dumoulin, A.; Stoeckli, E.T. Investigating Primary Cilia during Peripheral Nervous System Formation. Int. J. Mol. Sci. 2021, 22, 3176. https://doi.org/10.3390/ijms22063176

AMA Style

Yusifov E, Dumoulin A, Stoeckli ET. Investigating Primary Cilia during Peripheral Nervous System Formation. International Journal of Molecular Sciences. 2021; 22(6):3176. https://doi.org/10.3390/ijms22063176

Chicago/Turabian Style

Yusifov, Elkhan, Alexandre Dumoulin, and Esther T. Stoeckli. 2021. "Investigating Primary Cilia during Peripheral Nervous System Formation" International Journal of Molecular Sciences 22, no. 6: 3176. https://doi.org/10.3390/ijms22063176

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