Nitric Oxide (NO) Scaffolds the Peroxisomal Protein–Protein Interaction Network in Higher Plants
Abstract
:1. Overview of the Diversity of Peroxisomes in Eukaryotic Cells
2. Hydrogen Peroxide (H2O2) and Nitric Oxide (NO) Metabolism in Plant Peroxisomes
3. NO and Protein–Protein Interactions (PPIs) in Plant Peroxisomes
4. Can NO Be a Signal Which Scaffolds Peroxisomal Function?
5. Conclusions and Future Trials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Organism/Organ (Species) | Peroxisomal Function | Ref. |
---|---|---|
Free-living marine diplonemid (Diplonema papillatum) | Peroxisome undergoes remodeling metabolism involving the housing gluconeogenesis | [19] |
Ascomycete (Sclerotinia sclerotiorum) | Peroxisome is involved in the fungi sexual development | [20] |
Fungus (Alternaria alternate) | Peroxisome of the fungus is necessary for its pathogenesis in citrus | [21] |
Chlamydomonas | Peroxisomal malate dehydrogenase 2 connects lipid catabolism to photosynthesis | [22,23] |
Pea leaves (Pisum sativum) | Peroxisomes involve in leaf senescence | [24,25] |
Leaf tomato (Solanum lycopersicum) | Peroxisomes involve in pathogen defence | [26,27] |
Leaves (Arabidopsis thaliana) | Peroxisomal NADP-isocitrate dehydrogenase is required for stomatal movementPeroxisomal trehalose-6-phosphate phosphatase I is essential for flowering and development | [28,29] |
Petunia (Petunia hybrida) | Peroxisomal and chloroplastic chorismate synthase, involved in shikimate pathway, are need for flower development | [30] |
Mussels (Mytilus edulis) | Peroxisome proliferation in response to environmental pollutants | [31] |
Nile tilapia (Oreochromis niloticus) | Impaired of peroxisomal fat oxidation induces hepatic lipid accumulation and oxidative damage | [32] |
Rat liver (Rattus norvegicus) | Peroxisomes participate in the metabolism of xenobiotic acyl compounds | [33] |
Human (Homo sapiens) | Defects in genes encoding peroxisomal proteins lead to a variety of human diseases. For example, X-linked adrenoleukodystrophy, acatalasemia, cerebro-hepato-renal syndrome, etc.Host defense | [34,35,36,37,38] |
Peroxisomal Enzyme | NO-Derived PTM | Effect on Activity |
---|---|---|
Antioxidants | ||
Catalase (CAT) | Tyr-nitration S-nitrosation | Inhibition Inhibition |
Monodehydroascorbate reductase (MDAR) | Tyr-nitration S-nitrosation | Inhibition Inhibition |
Ascorbate peroxidase (APX) | Tyr-nitration S-nitrosation | Inhibition Activation |
CuZn-superoxide dismutase (CSD3) | Tyr-nitration | Inhibition |
Photorespiration | ||
Hydroxypyruvate reductase (HPR) | Tyr-nitration S-nitrosation | Inhibition Inhibition |
Glycolate oxidase (GOX) | S-nitrosation | Inhibition |
Fatty acid β-oxidation | ||
Malate dehydrogenase (MDH) | Tyr-nitration S-nitrosation | Inhibition Inhibition |
Isocitrate lyase (ICL) | S-nitrosation | Not reported |
Multifunctional protein AIM1 isoform | S-nitrosation | Not reported |
Glyoxylate cycle | ||
Isocitrate lyase (ICL) | S-nitrosation | Not reported |
Peroxisomal protein import | ||
Lon protease homolog 2 | S-nitrosation | Not reported |
NADPH supply | ||
NADP-isocitrate dehydrogenase (NADP-ICDH) | Tyr-nitration S-nitrosation | Inhibition Inhibition |
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Corpas, F.J.; González-Gordo, S.; Palma, J.M. Nitric Oxide (NO) Scaffolds the Peroxisomal Protein–Protein Interaction Network in Higher Plants. Int. J. Mol. Sci. 2021, 22, 2444. https://doi.org/10.3390/ijms22052444
Corpas FJ, González-Gordo S, Palma JM. Nitric Oxide (NO) Scaffolds the Peroxisomal Protein–Protein Interaction Network in Higher Plants. International Journal of Molecular Sciences. 2021; 22(5):2444. https://doi.org/10.3390/ijms22052444
Chicago/Turabian StyleCorpas, Francisco J., Salvador González-Gordo, and José M. Palma. 2021. "Nitric Oxide (NO) Scaffolds the Peroxisomal Protein–Protein Interaction Network in Higher Plants" International Journal of Molecular Sciences 22, no. 5: 2444. https://doi.org/10.3390/ijms22052444