Next Article in Journal
Injury-Induced Innate Immune Response During Segment Regeneration of the Earthworm, Eisenia andrei
Next Article in Special Issue
Silver Nanoparticles Modulate the Epithelial-to-Mesenchymal Transition in Estrogen-Dependent Breast Cancer Cells In Vitro
Previous Article in Journal
Role of Retinal Amyloid-β in Neurodegenerative Diseases: Overlapping Mechanisms and Emerging Clinical Applications
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 22
Issue 5
10.3390/ijms22052361
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Transient Vasodilation in Mouse 4T1 Tumors after Intragastric and Intravenous Administration of Gold Nanoparticles

by
Kamil Brzoska
1,
Małgorzata Szczygiel
2,
Agnieszka Drzał
2,
Martyna Sniegocka
2,
Dominika Michalczyk-Wetula
2,
Eva Biela
2,
Martyna Elas
2,
Lucyna Kapka-Skrzypczak
3,4,
Hanna Lewandowska-Siwkiewicz
1,
Krystyna Urbańska
2 and
Marcin Kruszewski
1,3,*
1
Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland
2
Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland
3
Department of Molecular Biology and Translational Research, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland
4
World Institute for Family Health, Calisia University, 62-800 Kalisz, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(5), 2361; https://doi.org/10.3390/ijms22052361
Submission received: 22 January 2021 / Revised: 18 February 2021 / Accepted: 22 February 2021 / Published: 26 February 2021
(This article belongs to the Special Issue Interactions of Nanomaterials with Biological Matrices)
Browse Figures
Review Reports Versions Notes

Abstract

Gold nanoparticles (AuNPs) are foreseen as a promising tool in nanomedicine, both as drug carriers and radiosensitizers. They have been also proposed as a potential anticancer drug due to the anti-angiogenic effect in tumor tissue. In this work we investigated the effect of citrate-coated AuNPs of nominal diameter 20 nm on the growth and metastatic potential of 4T1 cells originated from a mouse mammary gland tumor inoculated into the mammary fat pad of Balb/ccmdb mice. To evaluate whether AuNPs can prevent the tumor growth, one group of inoculated mice was intragastrically (i.g.) administered with 1 mg/kg of AuNPs daily from day 1 to day 14 after cancer cell implantation. To evaluate whether AuNPs can attenuate the tumor growth, the second group was intravenously (i.v.) administered with 1 or 5 mg/kg of AuNPs, twice on day 5 and day 14 after inoculation. We did not observe any anticancer activity of i.v. nor i.g. administered AuNPs, as they did not affect neither the primary tumor growth rate nor the number of lung metastases. Unexpectedly, both AuNP treatment regimens caused a marked vasodilating effect in the tumor tissue. As no change of potential angiogenic genes (Fgf2, Vegfa) nor inducible nitric oxygenase (Nos2) was observed, we proposed that the vasodilation was caused by AuNP-dependent decomposition of nitrosothiols and direct release of nitric oxide in the tumor tissue.
Keywords: gold nanoparticles; nitric oxide; vasodilation; S-nitrosothiols gold nanoparticles; nitric oxide; vasodilation; S-nitrosothiols

Share and Cite

MDPI and ACS Style

Brzoska, K.; Szczygiel, M.; Drzał, A.; Sniegocka, M.; Michalczyk-Wetula, D.; Biela, E.; Elas, M.; Kapka-Skrzypczak, L.; Lewandowska-Siwkiewicz, H.; Urbańska, K.; et al. Transient Vasodilation in Mouse 4T1 Tumors after Intragastric and Intravenous Administration of Gold Nanoparticles. Int. J. Mol. Sci. 2021, 22, 2361. https://doi.org/10.3390/ijms22052361

AMA Style

Brzoska K, Szczygiel M, Drzał A, Sniegocka M, Michalczyk-Wetula D, Biela E, Elas M, Kapka-Skrzypczak L, Lewandowska-Siwkiewicz H, Urbańska K, et al. Transient Vasodilation in Mouse 4T1 Tumors after Intragastric and Intravenous Administration of Gold Nanoparticles. International Journal of Molecular Sciences. 2021; 22(5):2361. https://doi.org/10.3390/ijms22052361

Chicago/Turabian Style

Brzoska, Kamil, Małgorzata Szczygiel, Agnieszka Drzał, Martyna Sniegocka, Dominika Michalczyk-Wetula, Eva Biela, Martyna Elas, Lucyna Kapka-Skrzypczak, Hanna Lewandowska-Siwkiewicz, Krystyna Urbańska, and et al. 2021. "Transient Vasodilation in Mouse 4T1 Tumors after Intragastric and Intravenous Administration of Gold Nanoparticles" International Journal of Molecular Sciences 22, no. 5: 2361. https://doi.org/10.3390/ijms22052361

APA Style

Brzoska, K., Szczygiel, M., Drzał, A., Sniegocka, M., Michalczyk-Wetula, D., Biela, E., Elas, M., Kapka-Skrzypczak, L., Lewandowska-Siwkiewicz, H., Urbańska, K., & Kruszewski, M. (2021). Transient Vasodilation in Mouse 4T1 Tumors after Intragastric and Intravenous Administration of Gold Nanoparticles. International Journal of Molecular Sciences, 22(5), 2361. https://doi.org/10.3390/ijms22052361

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop