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Neurometals in the Pathogenesis of Prion Diseases
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Neuroinflammation in Prion Disease

by , and *
School of Basic Medical Sciences, Fudan University, Dong’An Rd 130, Shanghai 200032, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Byung-Hoon Jeong
Int. J. Mol. Sci. 2021, 22(4), 2196; https://doi.org/10.3390/ijms22042196
Received: 10 February 2021 / Revised: 20 February 2021 / Accepted: 20 February 2021 / Published: 23 February 2021
(This article belongs to the Special Issue Molecular Genetics of Prion Diseases)
Neuroinflammation, typically manifest as microglial activation and astrogliosis accompanied by transcriptomic alterations, represents a common hallmark of various neurodegenerative conditions including prion diseases. Microglia play an overall neuroprotective role in prion disease, whereas reactive astrocytes with aberrant phenotypes propagate prions and contribute to prion-induced neurodegeneration. The existence of heterogeneous subpopulations and dual functions of microglia and astrocytes in prion disease make them potential targets for therapeutic intervention. A variety of neuroinflammation-related molecules are involved in prion pathogenesis. Therapeutics targeting neuroinflammation represents a novel approach to combat prion disease. Deciphering neuroinflammation in prion disease will deepen our understanding of pathogenesis of other neurodegenerative disorders. View Full-Text
Keywords: neuroinflammation; prion disease; microglial activation; astrogliosis; neurodegenerative disease neuroinflammation; prion disease; microglial activation; astrogliosis; neurodegenerative disease
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MDPI and ACS Style

Li, B.; Chen, M.; Zhu, C. Neuroinflammation in Prion Disease. Int. J. Mol. Sci. 2021, 22, 2196. https://doi.org/10.3390/ijms22042196

AMA Style

Li B, Chen M, Zhu C. Neuroinflammation in Prion Disease. International Journal of Molecular Sciences. 2021; 22(4):2196. https://doi.org/10.3390/ijms22042196

Chicago/Turabian Style

Li, Bei; Chen, Meiling; Zhu, Caihong. 2021. "Neuroinflammation in Prion Disease" Int. J. Mol. Sci. 22, no. 4: 2196. https://doi.org/10.3390/ijms22042196

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