Next Article in Journal
The Multiple Cellular Roles of SMUG1 in Genome Maintenance and Cancer
Next Article in Special Issue
Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial
Previous Article in Journal
Recent Advances in Stem Cell Therapies to Address Neuroinflammation, Stem Cell Survival, and the Need for Rehabilitative Therapies to Treat Traumatic Brain Injuries
Previous Article in Special Issue
The Role of Nucleotide Excision Repair in Cisplatin-Induced Peripheral Neuropathy: Mechanism, Prevention, and Treatment
Review

Peripheral Neuropathy under Oncologic Therapies: A Literature Review on Pathogenetic Mechanisms

1
Pharmacy Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, Viale Orazio Flacco 65, 70124 Bari, Italy
2
Interventional and Medical Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, Viale Orazio Flacco65, 70124 Bari, Italy
3
Department of Biomedical Sciences and Human Oncology, University of Bari ‘Aldo Moro’, 70121 Bari, Italy
4
Section of Pharmacology, Department of Pharmacy-Pharmaceutical Sciences, University of Bari, Via Orabona 4, 70125 Bari, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Nobuaki Egashira
Int. J. Mol. Sci. 2021, 22(4), 1980; https://doi.org/10.3390/ijms22041980
Received: 30 November 2020 / Revised: 5 February 2021 / Accepted: 7 February 2021 / Published: 17 February 2021
(This article belongs to the Special Issue Mechanisms of Chemotherapy-Induced Peripheral Neuropathy)
Peripheral neurologic complications are frequent adverse events during oncologic treatments and often lead to dose reduction, administration delays with time elongation of the therapeutic plan and, not least, worsening of patients’ quality of life. Experience skills are required to recognize symptoms and clinical evidences and the collaboration between different health professionals, in particular oncologists and hospital pharmacists, grants a correct management of this undesirable occurrence. Some classes of drugs (platinates, vinca alkaloids, taxanes) typically develop this kind of side effect, but the genesis of chemotherapy-induced peripheral neuropathy is not linked to a single mechanism. This paper aims from one side at summarizing and explaining all the scattering mechanisms of chemotherapy-induced peripheral neuropathy through a detailed literature revision, on the other side at finding new approaches to possible treatments, in order to facilitate the collaboration between oncologists, hematologists and hospital pharmacists. View Full-Text
Keywords: neurotoxicity; anti-cancer drugs; pharmacology; chemotherapy-induced peripheral neuropathy; neurodegeneration; mechanism neurotoxicity; anti-cancer drugs; pharmacology; chemotherapy-induced peripheral neuropathy; neurodegeneration; mechanism
MDPI and ACS Style

Laforgia, M.; Laface, C.; Calabrò, C.; Ferraiuolo, S.; Ungaro, V.; Tricarico, D.; Gadaleta, C.D.; Nardulli, P.; Ranieri, G. Peripheral Neuropathy under Oncologic Therapies: A Literature Review on Pathogenetic Mechanisms. Int. J. Mol. Sci. 2021, 22, 1980. https://doi.org/10.3390/ijms22041980

AMA Style

Laforgia M, Laface C, Calabrò C, Ferraiuolo S, Ungaro V, Tricarico D, Gadaleta CD, Nardulli P, Ranieri G. Peripheral Neuropathy under Oncologic Therapies: A Literature Review on Pathogenetic Mechanisms. International Journal of Molecular Sciences. 2021; 22(4):1980. https://doi.org/10.3390/ijms22041980

Chicago/Turabian Style

Laforgia, Mariarita, Carmelo Laface, Concetta Calabrò, Simona Ferraiuolo, Valentina Ungaro, Domenico Tricarico, Cosmo D. Gadaleta, Patrizia Nardulli, and Girolamo Ranieri. 2021. "Peripheral Neuropathy under Oncologic Therapies: A Literature Review on Pathogenetic Mechanisms" International Journal of Molecular Sciences 22, no. 4: 1980. https://doi.org/10.3390/ijms22041980

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop