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Open AccessReview

Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases

Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, 5 Fu-hsing Street, Gueishan, Taoyuan 333, Taiwan
Academic Editor: Rivka Ofir
Int. J. Mol. Sci. 2021, 22(4), 1769; https://doi.org/10.3390/ijms22041769
Received: 31 December 2020 / Revised: 1 February 2021 / Accepted: 7 February 2021 / Published: 10 February 2021
(This article belongs to the Special Issue hiPSC-Derived Cells as Models for Drug Discovery)
Recently, an increasing number of studies have demonstrated that induced pluripotent stem cells (iPSCs) and iPSC-derived cells display therapeutic effects, mainly via the paracrine mechanism in addition to their transdifferentiation ability. Exosomes have emerged as an important paracrine factor for iPSCs to repair injured cells through the delivery of bioactive components. Animal reports of iPSC-derived exosomes on various disease models are increasing, such as in heart, limb, liver, skin, bone, eye and neurological disease and so forth. This review aims to summarize the therapeutic effects of iPSC-derived exosomes on various disease models and their properties, such as angiogenesis, cell proliferation and anti-apoptosis, with the hopes of improving their potential role in clinical applications and functional restoration. View Full-Text
Keywords: induced pluripotent stem cells; exosome; cell-free regenerative medicine induced pluripotent stem cells; exosome; cell-free regenerative medicine
MDPI and ACS Style

Wang, A.Y.L. Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases. Int. J. Mol. Sci. 2021, 22, 1769. https://doi.org/10.3390/ijms22041769

AMA Style

Wang AYL. Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases. International Journal of Molecular Sciences. 2021; 22(4):1769. https://doi.org/10.3390/ijms22041769

Chicago/Turabian Style

Wang, Aline Y.L. 2021. "Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases" Int. J. Mol. Sci. 22, no. 4: 1769. https://doi.org/10.3390/ijms22041769

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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