Next Article in Journal
Role of Site-Specific Glycosylation in the I-Like Domain of Integrin β1 in Small Extracellular Vesicle-Mediated Malignant Behavior and FAK Activation
Next Article in Special Issue
Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes
Previous Article in Journal
Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases
Previous Article in Special Issue
The Role of Oxidative Stress in Pancreatic β Cell Dysfunction in Diabetes
Open AccessReview

Crosstalk between Macrophages and Pancreatic β-Cells in Islet Development, Homeostasis and Disease

1
Department of Fundamental Neurosciences, University of Lausanne, Rue du Bugnon 9, CH-1005 Lausanne, Switzerland
2
Department of Biomedical Sciences, University of Lausanne, Rue du Bugnon 7, CH-1005 Lausanne, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Hisamitsu Ishihara
Int. J. Mol. Sci. 2021, 22(4), 1765; https://doi.org/10.3390/ijms22041765
Received: 27 December 2020 / Revised: 4 February 2021 / Accepted: 6 February 2021 / Published: 10 February 2021
(This article belongs to the Special Issue Journey inside the Beta Cells in Type 2 Diabetes)
Macrophages are highly heterogeneous and plastic immune cells with peculiar characteristics dependent on their origin and microenvironment. Following pathogen infection or damage, circulating monocytes can be recruited in different tissues where they differentiate into macrophages. Stimuli present in the surrounding milieu induce the polarisation of macrophages towards a pro-inflammatory or anti-inflammatory profile, mediating inflammatory or homeostatic responses, respectively. However, macrophages can also derive from embryonic hematopoietic precursors and reside in specific tissues, actively participating in the development and the homeostasis in physiological conditions. Pancreatic islet resident macrophages are present from the prenatal stages onwards and show specific surface markers and functions. They localise in close proximity to β-cells, being exquisite sensors of their secretory ability and viability. Over the years, the crucial role of macrophages in β-cell differentiation and homeostasis has been highlighted. In addition, macrophages are emerging as central players in the initiation of autoimmune insulitis in type 1 diabetes and in the low-grade chronic inflammation characteristic of obesity and type 2 diabetes pathogenesis. The present work reviews the current knowledge in the field, with a particular focus on the mechanisms of communication between β-cells and macrophages that have been described so far. View Full-Text
Keywords: pancreatic islet; macrophage; diabetes pancreatic islet; macrophage; diabetes
Show Figures

Figure 1

MDPI and ACS Style

Cosentino, C.; Regazzi, R. Crosstalk between Macrophages and Pancreatic β-Cells in Islet Development, Homeostasis and Disease. Int. J. Mol. Sci. 2021, 22, 1765. https://doi.org/10.3390/ijms22041765

AMA Style

Cosentino C, Regazzi R. Crosstalk between Macrophages and Pancreatic β-Cells in Islet Development, Homeostasis and Disease. International Journal of Molecular Sciences. 2021; 22(4):1765. https://doi.org/10.3390/ijms22041765

Chicago/Turabian Style

Cosentino, Cristina; Regazzi, Romano. 2021. "Crosstalk between Macrophages and Pancreatic β-Cells in Islet Development, Homeostasis and Disease" Int. J. Mol. Sci. 22, no. 4: 1765. https://doi.org/10.3390/ijms22041765

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop