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Article

Deficiency of T-Cell Intracellular Antigen 1 in Murine Embryonic Fibroblasts Is Associated with Changes in Mitochondrial Morphology and Respiration

Centro de Biología Molecular ‘Severo Ochoa’, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), C/Nicolás Cabrera 1, Cantoblanco, 28049 Madrid, Spain
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Michael Welsh
Int. J. Mol. Sci. 2021, 22(23), 12775; https://doi.org/10.3390/ijms222312775
Received: 3 November 2021 / Revised: 22 November 2021 / Accepted: 24 November 2021 / Published: 26 November 2021
(This article belongs to the Collection Feature Papers in Molecular Oncology)
T-cell intracellular antigen 1 (TIA1) is a multifunctional RNA-binding protein involved in regulating gene expression and splicing during development and in response to environmental stress, to maintain cell homeostasis and promote survival. Herein, we used TIA1-deficient murine embryonic fibroblasts (MEFs) to study their role in mitochondria homeostasis. We found that the loss of TIA1 was associated with changes in mitochondrial morphology, promoting the appearance of elongated mitochondria with heterogeneous cristae density and size. The proteomic patterns of TIA1-deficient MEFs were consistent with expression changes in molecular components related to mitochondrial dynamics/organization and respiration. Bioenergetics analysis illustrated that TIA1 deficiency enhances mitochondrial respiration. Overall, our findings shed light on the role of TIA1 in mitochondrial dynamics and highlight a point of crosstalk between potential pro-survival and pro-senescence pathways. View Full-Text
Keywords: TIA1; mitochondria; mitochondrial dynamics; mitochondrial respiration; murine embryonic fibroblast TIA1; mitochondria; mitochondrial dynamics; mitochondrial respiration; murine embryonic fibroblast
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MDPI and ACS Style

Carrascoso, I.; Velasco, B.R.; Izquierdo, J.M. Deficiency of T-Cell Intracellular Antigen 1 in Murine Embryonic Fibroblasts Is Associated with Changes in Mitochondrial Morphology and Respiration. Int. J. Mol. Sci. 2021, 22, 12775. https://doi.org/10.3390/ijms222312775

AMA Style

Carrascoso I, Velasco BR, Izquierdo JM. Deficiency of T-Cell Intracellular Antigen 1 in Murine Embryonic Fibroblasts Is Associated with Changes in Mitochondrial Morphology and Respiration. International Journal of Molecular Sciences. 2021; 22(23):12775. https://doi.org/10.3390/ijms222312775

Chicago/Turabian Style

Carrascoso, Isabel, Beatriz R. Velasco, and José M. Izquierdo. 2021. "Deficiency of T-Cell Intracellular Antigen 1 in Murine Embryonic Fibroblasts Is Associated with Changes in Mitochondrial Morphology and Respiration" International Journal of Molecular Sciences 22, no. 23: 12775. https://doi.org/10.3390/ijms222312775

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