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Mesenchymal Stem Cell-Derived Extracellular Vesicle: A Promising Alternative Therapy for Osteoporosis

by 1,2, 3,4, 5,6,7,* and 3,4,8,9,10,*
1
Core Laboratory for Phenomics and Diagnostics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
2
Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
3
Molecular and Genetic Imaging Core/Taiwan Mouse Clinic, National Comprehensive Mouse Phenotyping and Drug Testing Center, Taipei 112, Taiwan
4
Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
5
Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan
6
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
7
Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan
8
Department of Nuclear Medicine, Cheng Hsin General Hospital, Taipei 112, Taiwan
9
Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
10
PET Center, Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editors: Heba Abdelrazik, Elena De Falco, Alessandra Pelagalli and Sara Perteghella
Int. J. Mol. Sci. 2021, 22(23), 12750; https://doi.org/10.3390/ijms222312750 (registering DOI)
Received: 25 October 2021 / Revised: 15 November 2021 / Accepted: 22 November 2021 / Published: 25 November 2021
Osteoporosis is the chronic metabolic bone disease caused by the disturbance of bone remodeling due to the imbalance of osteogenesis and osteoclastogenesis. A large population suffers from osteoporosis, and most of them are postmenopausal women or older people. To date, bisphosphonates are the main therapeutic agents in the treatment of osteoporosis. However, limited therapeutic effects with diverse side effects caused by bisphosphonates hindered the therapeutic applications and decreased the quality of life. Therefore, an alternative therapy for osteoporosis is still needed. Stem cells, especially mesenchymal stem cells, have been shown as a promising medication for numerous human diseases including many refractory diseases. Recently, researchers found that the extracellular vesicles derived from these stem cells possessed the similar therapeutic potential to that of parental cells. To date, a number of studies demonstrated the therapeutic applications of exogenous MSC-EVs for the treatment of osteoporosis. In this article, we reviewed the basic back ground of EVs, the cargo and therapeutic potential of MSC-EVs, and strategies of engineering of MSC-EVs for osteoporosis treatment. View Full-Text
Keywords: osteoporosis; mesenchymal stem cells; extracellular vesicles; EV cargo; engineering EV; osteoporosis medications osteoporosis; mesenchymal stem cells; extracellular vesicles; EV cargo; engineering EV; osteoporosis medications
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MDPI and ACS Style

Lu, C.-H.; Chen, Y.-A.; Ke, C.-C.; Liu, R.-S. Mesenchymal Stem Cell-Derived Extracellular Vesicle: A Promising Alternative Therapy for Osteoporosis. Int. J. Mol. Sci. 2021, 22, 12750. https://doi.org/10.3390/ijms222312750

AMA Style

Lu C-H, Chen Y-A, Ke C-C, Liu R-S. Mesenchymal Stem Cell-Derived Extracellular Vesicle: A Promising Alternative Therapy for Osteoporosis. International Journal of Molecular Sciences. 2021; 22(23):12750. https://doi.org/10.3390/ijms222312750

Chicago/Turabian Style

Lu, Cheng-Hsiu, Yi-An Chen, Chien-Chih Ke, and Ren-Shyan Liu. 2021. "Mesenchymal Stem Cell-Derived Extracellular Vesicle: A Promising Alternative Therapy for Osteoporosis" International Journal of Molecular Sciences 22, no. 23: 12750. https://doi.org/10.3390/ijms222312750

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