Next Article in Journal
Self-Assembling Peptides: From Design to Biomedical Applications
Next Article in Special Issue
Bacterial Outer Membrane Protein OmpX Regulates β1 Integrin and Epidermal Growth Factor Receptor (EGFR) Involved in Invasion of M-HeLa Cells by Serratia proteamaculans
Previous Article in Journal
Effect of Tempeh on Gut Microbiota and Anti-Stress Activity in Zebrafish
Previous Article in Special Issue
Enterococcus faecium Regulates Honey Bee Developmental Genes
Review

Implications of Gut Microbiota in Complex Human Diseases

1
Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun 130012, China
2
Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands
3
Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland
4
Vascular Biology Program, Department of Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA
5
Department of Genetics and Genomics, Mydnavar, 2645 Somerset Boulevard, Troy, MI 48084, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Rustam I. Aminov
Int. J. Mol. Sci. 2021, 22(23), 12661; https://doi.org/10.3390/ijms222312661
Received: 21 October 2021 / Revised: 30 October 2021 / Accepted: 17 November 2021 / Published: 23 November 2021
(This article belongs to the Special Issue Host-Microbe Interaction 3.0)
Humans, throughout the life cycle, from birth to death, are accompanied by the presence of gut microbes. Environmental factors, lifestyle, age and other factors can affect the balance of intestinal microbiota and their impact on human health. A large amount of data show that dietary, prebiotics, antibiotics can regulate various diseases through gut microbes. In this review, we focus on the role of gut microbes in the development of metabolic, gastrointestinal, neurological, immune diseases and, cancer. We also discuss the interaction between gut microbes and the host with respect to their beneficial and harmful effects, including their metabolites, microbial enzymes, small molecules and inflammatory molecules. More specifically, we evaluate the potential ability of gut microbes to cure diseases through Fecal Microbial Transplantation (FMT), which is expected to become a new type of clinical strategy for the treatment of various diseases. View Full-Text
Keywords: gut; microbiota; disease; bacteria; FMT gut; microbiota; disease; bacteria; FMT
Show Figures

Figure 1

MDPI and ACS Style

Yu, D.; Meng, X.; de Vos, W.M.; Wu, H.; Fang, X.; Maiti, A.K. Implications of Gut Microbiota in Complex Human Diseases. Int. J. Mol. Sci. 2021, 22, 12661. https://doi.org/10.3390/ijms222312661

AMA Style

Yu D, Meng X, de Vos WM, Wu H, Fang X, Maiti AK. Implications of Gut Microbiota in Complex Human Diseases. International Journal of Molecular Sciences. 2021; 22(23):12661. https://doi.org/10.3390/ijms222312661

Chicago/Turabian Style

Yu, Dahai, Xin Meng, Willem M. de Vos, Hao Wu, Xuexun Fang, and Amit K. Maiti. 2021. "Implications of Gut Microbiota in Complex Human Diseases" International Journal of Molecular Sciences 22, no. 23: 12661. https://doi.org/10.3390/ijms222312661

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop