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Implications of Gut Microbiota in Complex Human Diseases

Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun 130012, China
Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands
Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland
Vascular Biology Program, Department of Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA
Department of Genetics and Genomics, Mydnavar, 2645 Somerset Boulevard, Troy, MI 48084, USA
Authors to whom correspondence should be addressed.
Academic Editor: Rustam I. Aminov
Int. J. Mol. Sci. 2021, 22(23), 12661;
Received: 21 October 2021 / Revised: 30 October 2021 / Accepted: 17 November 2021 / Published: 23 November 2021
(This article belongs to the Special Issue Host-Microbe Interaction 3.0)
Humans, throughout the life cycle, from birth to death, are accompanied by the presence of gut microbes. Environmental factors, lifestyle, age and other factors can affect the balance of intestinal microbiota and their impact on human health. A large amount of data show that dietary, prebiotics, antibiotics can regulate various diseases through gut microbes. In this review, we focus on the role of gut microbes in the development of metabolic, gastrointestinal, neurological, immune diseases and, cancer. We also discuss the interaction between gut microbes and the host with respect to their beneficial and harmful effects, including their metabolites, microbial enzymes, small molecules and inflammatory molecules. More specifically, we evaluate the potential ability of gut microbes to cure diseases through Fecal Microbial Transplantation (FMT), which is expected to become a new type of clinical strategy for the treatment of various diseases. View Full-Text
Keywords: gut; microbiota; disease; bacteria; FMT gut; microbiota; disease; bacteria; FMT
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MDPI and ACS Style

Yu, D.; Meng, X.; de Vos, W.M.; Wu, H.; Fang, X.; Maiti, A.K. Implications of Gut Microbiota in Complex Human Diseases. Int. J. Mol. Sci. 2021, 22, 12661.

AMA Style

Yu D, Meng X, de Vos WM, Wu H, Fang X, Maiti AK. Implications of Gut Microbiota in Complex Human Diseases. International Journal of Molecular Sciences. 2021; 22(23):12661.

Chicago/Turabian Style

Yu, Dahai, Xin Meng, Willem M. de Vos, Hao Wu, Xuexun Fang, and Amit K. Maiti. 2021. "Implications of Gut Microbiota in Complex Human Diseases" International Journal of Molecular Sciences 22, no. 23: 12661.

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