Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease
Abstract
:1. Introduction
2. Crucial Modulators of Ferroptosis
2.1. GSH Homeostasis
2.2. Polyunsaturated Fatty Acids
2.3. Cellular Iron Pool
3. The Role of Ferroptosis in Gastrointestinal Disease
3.1. Intestinal I/R
3.2. The Role of Ferroptosis in IBD
3.3. The Role of Ferroptosis in Gastric Cancer (GC)
3.4. The Role of Ferroptosis in Colorectal Cancer (CRC)
4. Effects of Dietary Nutrients and Phytochemicals on Ferroptosis and Gastric Diseases
5. Conclusions and Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Gut Diseases | Genes | Compunds | Mechanism | References |
---|---|---|---|---|
Intestinal I/R | GPX4, ASCL4 | Lip-1 | Inhibit ferroptosis and ameliorate intestinal I/R | [30,39] |
Inflammatory bowel disease | GPX4, ASCL4, FTH1, NF-κBp65 | Lip-1, Fer-1, DFP, DFO | Inhibit ferroptosis and ameliorate inflammatory bowel disease | [40,41] |
Gastric cancer | GPX4, SLC7A11, SCD1, ELOVL5 and FADS1 | Apatinib, Erastin | Induce ferroptosis and inhibit gastric cancer | [26,42,43,44] |
Colorectal cancer | GPX4, SLC7A11, p53, HO-1 | Erastin, Cisplatin, Bromelain | Induce ferroptosis and inhibit colorectal cancer | [45,46] |
Ferroptosis Related Genes | References |
---|---|
GABARAPL1, ZFP36, DUSP1, TXNIP, NNMT, MYB, PSAT1, and CXCL2 | [70] |
AKAP12, DUSP1, EFNA3, LOX, PIM1, SERPINE1, STC1, and ZFP36 | [71] |
NOX4, NOX5, SLC1A5, GLS2, MYB, TGFBR1, NF2, ZFP36, DUSP1, SLC1A4, and SP1 | [72] |
TCFBR1, MYB, NFE2L2, ZFP36, TF, SLC1A5, NF2, and NOX4 | [73] |
Ferroptosis Related Genes | References |
---|---|
SLC2A3, ATF3, VLDLR, TXNIP, ZFP69B, ABCC1, NFS1, RRM2, and BID | [99] |
TFAP2C, SLC39A8, NOS2, HAMP, GDF15, FDFT1, CDKN2A, ALOX12, AKR1C1, ATP6V1G2 | [100] |
ATP6V1G2, DRD4, JDP2, SLC2A3 and VEGFA, ATG7, DUOX1, NOX4 and PGD | [101] |
AKR1C1, ALOX12, FDFT1, ATP5MC3, and CARS1 | [102] |
lncRNAs (LINC01503, AC004687.1, AC010973.2, AP001189.3, ARRDC1-AS1, OIP5-AS1, and NCK1-DT) | [97] |
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Xu, C.; Liu, Z.; Xiao, J. Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease. Int. J. Mol. Sci. 2021, 22, 12403. https://doi.org/10.3390/ijms222212403
Xu C, Liu Z, Xiao J. Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease. International Journal of Molecular Sciences. 2021; 22(22):12403. https://doi.org/10.3390/ijms222212403
Chicago/Turabian StyleXu, Chengfei, Ziling Liu, and Jiangwei Xiao. 2021. "Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease" International Journal of Molecular Sciences 22, no. 22: 12403. https://doi.org/10.3390/ijms222212403